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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NECAB1

Summary for NECAB1

Gene information	Gene symbol	NECAB1
	Ensembl ID	ENSG00000123119
	Entrez ID	64168
	Gene name	N-terminal EF-hand calcium binding protein 1
	Synonyms	EFCBP1
	Gene type	protein_coding
	UniProtAcc	Q8N987

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Dataset with differentially expressed gene: NECAB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.290126	4.14e-18

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Expression of NECAB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NECAB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NECAB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NECAB1	hsa-miR-8485	99.7085	NM_022351
NECAB1	hsa-miR-493-5p	98.9681	NM_022351
NECAB1	hsa-miR-576-5p	98.3097	NM_022351
NECAB1	hsa-miR-3658	97.776	NM_022351
NECAB1	hsa-miR-186-5p	95.2759	NM_022351
NECAB1	hsa-miR-580-3p	95.0794	NM_022351
NECAB1	hsa-miR-335-3p	94.912	NM_022351
NECAB1	hsa-miR-514b-5p	94.662	NM_022351
NECAB1	hsa-miR-372-5p	93.8378	NM_022351
NECAB1	hsa-miR-5701	93.4203	NM_022351
NECAB1	hsa-miR-513c-5p	93.3039	NM_022351
NECAB1	hsa-miR-5579-5p	93.3012	NM_022351
NECAB1	hsa-miR-4282	93.2653	NM_022351
NECAB1	hsa-miR-2054	92.9926	NM_022351
NECAB1	hsa-miR-3606-5p	91.5436	NM_022351
NECAB1	hsa-miR-4520-2-3p	90.4816	NM_022351
NECAB1	hsa-miR-6505-5p	90.4421	NM_022351
NECAB1	hsa-let-7c-3p	90.4221	NM_022351
NECAB1	hsa-miR-18a-3p	90.1115	NM_022351
NECAB1	hsa-miR-4775	89.8363	NM_022351
NECAB1	hsa-miR-3133	89.1972	NM_022351
NECAB1	hsa-miR-4773	88.4758	NM_022351
NECAB1	hsa-miR-5683	87.7358	NM_022351
NECAB1	hsa-let-7a-2-3p	87.5211	NM_022351
NECAB1	hsa-miR-590-3p	87.3533	NM_022351
NECAB1	hsa-miR-329-5p	87.0839	NM_022351
NECAB1	hsa-miR-27b-3p	86.5827	NM_022351
NECAB1	hsa-miR-9985	86.5827	NM_022351
NECAB1	hsa-miR-27a-3p	86.5827	NM_022351
NECAB1	hsa-miR-562	85.2136	NM_022351
NECAB1	hsa-let-7g-3p	85.1328	NM_022351
NECAB1	hsa-miR-6500-3p	84.9087	NM_022351
NECAB1	hsa-miR-571	84.7001	NM_022351
NECAB1	hsa-miR-3942-3p	83.168	NM_022351
NECAB1	hsa-miR-520f-5p	83.0153	NM_022351
NECAB1	hsa-miR-3074-5p	82.759	NM_022351
NECAB1	hsa-miR-3168	82.3523	NM_022351
NECAB1	hsa-miR-942-5p	82.1417	NM_022351
NECAB1	hsa-miR-3163	81.933	NM_022351
NECAB1	hsa-miR-1245b-3p	81.7372	NM_022351
NECAB1	hsa-miR-1277-5p	81.631	NM_022351
NECAB1	hsa-miR-181b-2-3p	81.0218	NM_022351
NECAB1	hsa-miR-4420	81.0218	NM_022351
NECAB1	hsa-miR-181b-3p	81.0218	NM_022351
NECAB1	hsa-miR-6504-3p	80.9298	NM_022351
NECAB1	hsa-miR-10399-5p	80.5288	NM_022351
NECAB1	hsa-miR-664a-3p	80.326	NM_022351
NECAB1	hsa-miR-4261	80.2994	NM_022351

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Motifs and transcription factors (TFs) regulating NECAB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NECAB1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
NECAB1	transfac_pro__M06534	ZNF563 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."