Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NDUFAF3

Summary for NDUFAF3

Gene information	Gene symbol	NDUFAF3
	Ensembl ID	ENSG00000178057
	Entrez ID	25915
	Gene name	NADH:ubiquinone oxidoreductase complex assembly factor 3
	Synonyms	2P1\|C3orf60\|DKFZP564J0123\|E3-3\|MGC10527
	Gene type	protein_coding
	UniProtAcc	Q9BU61

Top

Dataset with differentially expressed gene: NDUFAF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.707536	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.363785	3.01e-20
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.488002	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	-0.311469	2.93e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.499662	6.31e-36
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279901	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.40328	1.92e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.350128	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.450432	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.510031	1.40e-45
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.396756	5.62e-23
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.290306	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.713838	4.63e-29
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.365033	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.263229	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.871567	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.676935	0.00e+00

Top

Expression of NDUFAF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NDUFAF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NDUFAF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDUFAF3	hsa-miR-944	93.9818	NM_199069
NDUFAF3	hsa-miR-6755-5p	90.8383	NM_199070
NDUFAF3	hsa-miR-6871-5p	84.4712	NM_199070
NDUFAF3	hsa-miR-3132	83.4292	NM_199070
NDUFAF3	hsa-miR-197-5p	83.4292	NM_199070
NDUFAF3	hsa-miR-126-5p	81.2911	NM_199069

Page: 1

Top

Motifs and transcription factors (TFs) regulating NDUFAF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDUFAF3	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
NDUFAF3	transfac_pro__M02843	BBX (inferredBy_Orthology).
NDUFAF3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NDUFAF3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NDUFAF3	hdpi__TP73	TP73 (directAnnotation).
NDUFAF3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
NDUFAF3	transfac_pro__M04944	GABPA (directAnnotation).
NDUFAF3	transfac_pro__M04862	NRF1 (directAnnotation).
NDUFAF3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NDUFAF3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
NDUFAF3	metacluster_161.31	PRRX2 (directAnnotation).
NDUFAF3	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
NDUFAF3	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
NDUFAF3	transfac_pro__M06826	ZNF516 (inferredBy_Orthology).
NDUFAF3	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
NDUFAF3	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
NDUFAF3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
NDUFAF3	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
NDUFAF3	taipale_tf_pairs__TEAD4_HOXA13_GGWATGNNNRTAAA_CAP_repr	HOXA13; TEAD4 (directAnnotation).
NDUFAF3	taipale_tf_pairs__TEAD4_PITX1_RCATWCNNNNNGGATTA_CAP_repr	PITX1; TEAD4 (directAnnotation).
NDUFAF3	taipale_tf_pairs__TEAD4_HOXB13_GGWATGNNNRTAAA_CAP	HOXB13; TEAD4 (directAnnotation).
NDUFAF3	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
NDUFAF3	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).
NDUFAF3	metacluster_161.16	NKX3-2 (directAnnotation).
NDUFAF3	metacluster_172.8	SIX1 (directAnnotation).
NDUFAF3	transfac_pro__M04886	ETS1 (directAnnotation).
NDUFAF3	metacluster_161.30	BSX (directAnnotation).
NDUFAF3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
NDUFAF3	tfdimers__MD00336	IRF8; STAT1 (directAnnotation).
NDUFAF3	transfac_pro__M05787	ZNF546 (directAnnotation).
NDUFAF3	metacluster_161.15	NKX3-1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."