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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NDUFA5

Summary for NDUFA5

Gene information	Gene symbol	NDUFA5
	Ensembl ID	ENSG00000128609
	Entrez ID	4698
	Gene name	NADH:ubiquinone oxidoreductase subunit A5
	Synonyms	B13\|CI-13kB\|CI-13KD-B\|NUFM\|UQOR13
	Gene type	protein_coding
	UniProtAcc	Q16718

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Dataset with differentially expressed gene: NDUFA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.529412	1.95e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.495175	6.00e-34
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.351167	3.36e-31
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.598317	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.458991	9.53e-39
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.48789	1.29e-26
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.561846	1.26e-44
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.283562	2.02e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.3033	4.00e-11

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Expression of NDUFA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDUFA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDUFA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDUFA5	hsa-miR-8485	99.5391	NM_001282419
NDUFA5	hsa-miR-607	97.5367	NM_001282419
NDUFA5	hsa-miR-3662	96.9612	NM_001282419
NDUFA5	hsa-miR-6074	95.3767	NM_001282419
NDUFA5	hsa-miR-499a-5p	95.3005	NM_001282419
NDUFA5	hsa-miR-492	93.2625	NM_001282419
NDUFA5	hsa-miR-196a-1-3p	92.4835	NM_001282419
NDUFA5	hsa-miR-2052	90.8243	NM_001282419
NDUFA5	hsa-miR-380-3p	89.7798	NM_001282419
NDUFA5	hsa-miR-513c-3p	89.6646	NM_001282419
NDUFA5	hsa-miR-513a-3p	89.6646	NM_001282419
NDUFA5	hsa-miR-4303	89.5493	NM_001282419
NDUFA5	hsa-miR-488-3p	89.3086	NM_001282419
NDUFA5	hsa-miR-7702	89.2846	NM_001282419
NDUFA5	hsa-miR-32-3p	89.2475	NM_001282419
NDUFA5	hsa-miR-224-3p	88.8449	NM_001282419
NDUFA5	hsa-miR-522-3p	88.8449	NM_001282419
NDUFA5	hsa-miR-1233-5p	88.4637	NM_001282419
NDUFA5	hsa-miR-5696	87.2631	NM_001282419
NDUFA5	hsa-miR-656-3p	86.9902	NM_001282419
NDUFA5	hsa-miR-374a-5p	86.2722	NM_001282419
NDUFA5	hsa-miR-4310	85.9503	NM_001282419
NDUFA5	hsa-miR-630	85.9297	NM_001282419
NDUFA5	hsa-miR-590-3p	85.7311	NM_001282419
NDUFA5	hsa-miR-3671	85.6695	NM_001282419
NDUFA5	hsa-miR-374b-5p	85.6012	NM_001282419
NDUFA5	hsa-miR-551b-5p	84.9587	NM_001282419
NDUFA5	hsa-miR-494-3p	84.8413	NM_001282419
NDUFA5	hsa-miR-744-3p	84.8288	NM_001282419
NDUFA5	hsa-miR-3609	84.8265	NM_001282419
NDUFA5	hsa-miR-1252-5p	84.496	NM_001282419
NDUFA5	hsa-miR-3606-3p	84.2683	NM_001282419
NDUFA5	hsa-miR-3613-3p	83.3431	NM_001282419
NDUFA5	hsa-miR-5692a	83.0472	NM_001282419
NDUFA5	hsa-miR-23a-3p	82.4655	NM_001282419
NDUFA5	hsa-miR-23b-3p	82.4655	NM_001282419
NDUFA5	hsa-miR-23c	82.4655	NM_001282419
NDUFA5	hsa-miR-379-3p	82.0756	NM_001282419
NDUFA5	hsa-miR-411-3p	82.0756	NM_001282419
NDUFA5	hsa-miR-6778-5p	81.5519	NM_001282419
NDUFA5	hsa-miR-369-3p	80.8079	NM_001282419
NDUFA5	hsa-miR-548ah-5p	80.4727	NM_001282419
NDUFA5	hsa-miR-649	80.4618	NM_001282419

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Motifs and transcription factors (TFs) regulating NDUFA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDUFA5	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NDUFA5	transfac_pro__M00652	NRF1 (directAnnotation).
NDUFA5	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NDUFA5	swissregulon__hs__DMC1	DMC1 (directAnnotation).
NDUFA5	tfdimers__MD00208	IRF1; LTF (directAnnotation).
NDUFA5	jaspar__MA0776.1	MYBL1 (directAnnotation).
NDUFA5	transfac_pro__M05750	ZNF77 (directAnnotation).
NDUFA5	metacluster_22.29	NFE2 (directAnnotation).
NDUFA5	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
NDUFA5	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
NDUFA5	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NDUFA5	"NADH"	DB00157	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."