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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NDUFA11

Summary for NDUFA11

Gene information	Gene symbol	NDUFA11
	Ensembl ID	ENSG00000174886
	Entrez ID	126328
	Gene name	NADH:ubiquinone oxidoreductase subunit A11
	Synonyms	B14.7
	Gene type	protein_coding
	UniProtAcc	Q86Y39

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Dataset with differentially expressed gene: NDUFA11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.375561	5.89e-32
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.292096	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.481937	5.38e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.407026	1.21e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.253678	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	-0.342778	1.04e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	-0.326929	4.52e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.322432	2.95e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.260715	1.94e-09
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.478904	2.34e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.323121	1.13e-33
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.365655	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.281742	1.40e-04
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.26757	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-1.07852	0.00e+00

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Expression of NDUFA11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDUFA11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDUFA11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDUFA11	hsa-miR-3202	90.0293	NM_001193375
NDUFA11	hsa-miR-658	87.785	NM_001193375
NDUFA11	hsa-miR-4492	82.1932	NM_001193375

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Motifs and transcription factors (TFs) regulating NDUFA11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDUFA11	homer__NAACAGCTGG_Tcf21	TCF21 (directAnnotation).
NDUFA11	transfac_pro__M05798	ZNF517 (directAnnotation).
NDUFA11	transfac_pro__M06924	ZNF236 (directAnnotation).
NDUFA11	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
NDUFA11	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
NDUFA11	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
NDUFA11	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
NDUFA11	metacluster_142.4	POU2AF1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F3; POU2F3; POU2F3; POU2F3; POU2F3; POU3F1; POU3F2; POU3F3; POU4F1; POU5F1; POU5F1; POU5F1; POU5F1B; POU5F1B; POU5F1B; TBP (directAnnotation). CCDC160; CCDC160; CCDC160; CCDC160; CCDC160; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU3F1; POU3F1; POU3F1; POU3F1; POU3F1; POU3F3; POU3F3; POU3F3; POU3F3; POU3F3; POU3F3; POU3F4; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F2; POU5F2; POU5F2; POU5F2; POU5F2 (inferredBy_Orthology).
NDUFA11	transfac_pro__M05982	ZFP14 (directAnnotation).
NDUFA11	hocomoco__DPRX_HUMAN.H11MO.0.D	DPRX (directAnnotation).
NDUFA11	transfac_pro__M06512	ZNF461 (directAnnotation).
NDUFA11	metacluster_87.5	ZNF296 (directAnnotation).
NDUFA11	metacluster_168.16	FOXG1 (inferredBy_Orthology).
NDUFA11	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
NDUFA11	taipale_tf_pairs__CUX1_SOX15_NATCRATNNNNNNNAACAATRS_CAP_repr	CUX1; SOX15 (directAnnotation).
NDUFA11	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
NDUFA11	transfac_pro__M05560	AEBP2 (directAnnotation).
NDUFA11	tfdimers__MD00395	NKX2-1; OTX1; OTX2 (directAnnotation).
NDUFA11	transfac_pro__M01108	HOXA7 (directAnnotation).
NDUFA11	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NDUFA11	"NADH"	DB00157	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."