Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.565334 | 0.00e+00 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | -0.263561 | 2.43e-09 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Mono/Macro | -0.497144 | 1.06e-35 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | -1.59283 | 0.00e+00 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | B cells | -0.38837 | 5.97e-04 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | Malignant cells | -0.32517 | 2.49e-34 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -1.61236 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
NDRG1 | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
NDRG1 | transfac_pro__M07461 | KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation). |
NDRG1 | metacluster_135.8 | ZNF516; ZNF536 (inferredBy_Orthology). |
NDRG1 | metacluster_107.2 | CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology). |
NDRG1 | transfac_pro__M05521 | ZNF398 (directAnnotation). |
NDRG1 | taipale_tf_pairs__FOXJ2_HOXB13_RTAAACWNATWAAA_CAP_repr | FOXJ2; HOXB13 (directAnnotation). |
NDRG1 | transfac_pro__M05539 | OSR2 (inferredBy_Orthology). |
NDRG1 | jaspar__MA1954.1 | FOXO1 (directAnnotation). |
NDRG1 | metacluster_93.4 | BCL6B (directAnnotation). |
NDRG1 | metacluster_155.27 | ZFX; ZNF667 (directAnnotation). |
NDRG1 | dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1 | ZFP91 (directAnnotation). |
NDRG1 | transfac_pro__M06277 | ZNF404 (directAnnotation). |
NDRG1 | hdpi__YEATS4 | YEATS4 (directAnnotation). |
NDRG1 | metacluster_22.29 | NFE2 (directAnnotation). |
NDRG1 | taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2 | ELK1; GCM1 (directAnnotation). |
NDRG1 | metacluster_22.21 | NFE2L2 (inferredBy_Orthology). |
NDRG1 | metacluster_22.13 | MAFK (inferredBy_Orthology). |
NDRG1 | tfdimers__MD00208 | IRF1; LTF (directAnnotation). |
NDRG1 | metacluster_22.12 | NFE2; NFE2L1 (directAnnotation). |
NDRG1 | hocomoco__TYY2_HUMAN.H11MO.0.D | YY2 (directAnnotation). |
NDRG1 | transfac_pro__M07392 | PITX3 (directAnnotation). |
NDRG1 | metacluster_141.4 | GLIS2 (directAnnotation). |
NDRG1 | metacluster_22.19 | NFE2 (directAnnotation). |
NDRG1 | metacluster_22.18 | BACH2 (inferredBy_Orthology). |
NDRG1 | metacluster_22.37 | BACH1 (directAnnotation). |
NDRG1 | metacluster_22.36 | BACH2 (directAnnotation). |
NDRG1 | metacluster_22.34 | BACH2 (directAnnotation). |
NDRG1 | metacluster_22.20 | MAFG (directAnnotation). |
NDRG1 | metacluster_22.35 | MAFK (directAnnotation). |
NDRG1 | metacluster_22.16 | BACH2 (directAnnotation). |
NDRG1 | metacluster_22.11 | NFE2 (directAnnotation). |
NDRG1 | metacluster_157.2 | ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology). |
NDRG1 | metacluster_22.33 | MAFK (inferredBy_Orthology). |
NDRG1 | metacluster_22.32 | NFE2L2 (directAnnotation). |
NDRG1 | metacluster_32.24 | ZNF287 (directAnnotation). |
NDRG1 | metacluster_137.2 | ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology). |
NDRG1 | metacluster_22.17 | NFE2 (directAnnotation). |
NDRG1 | metacluster_30.4 | BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation). |
NDRG1 | hocomoco__OTX1_HUMAN.H11MO.0.D | OTX1 (directAnnotation). |
NDRG1 | hdpi__TP73 | TP73 (directAnnotation). |
NDRG1 | transfac_pro__M06135 | ZNF28 (directAnnotation). |
NDRG1 | transfac_pro__M04886 | ETS1 (directAnnotation). |
NDRG1 | transfac_pro__M04913 | ZBTB7A (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |