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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NDFIP2

Summary for NDFIP2

Gene information	Gene symbol	NDFIP2
	Ensembl ID	ENSG00000102471
	Entrez ID	54602
	Gene name	Nedd4 family interacting protein 2
	Synonyms	KIAA1165\|N4wbp5a
	Gene type	protein_coding
	UniProtAcc	Q9NV92

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Dataset with differentially expressed gene: NDFIP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.355371	4.64e-23
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.296938	0.00e+00

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Expression of NDFIP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDFIP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDFIP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDFIP2	hsa-miR-3646	99.5576	NM_001161407
NDFIP2	hsa-miR-5692a	99.5126	NM_001161407
NDFIP2	hsa-miR-6740-3p	99.4811	NM_001161407
NDFIP2	hsa-miR-5011-5p	99.2941	NM_001161407
NDFIP2	hsa-miR-590-3p	99.0149	NM_001161407
NDFIP2	hsa-miR-410-3p	98.7329	NM_001161407
NDFIP2	hsa-miR-5009-3p	98.6407	NM_001161407
NDFIP2	hsa-miR-4775	97.4614	NM_001161407
NDFIP2	hsa-miR-548c-3p	97.0404	NM_001161407
NDFIP2	hsa-miR-200b-5p	95.7335	NM_001161407
NDFIP2	hsa-miR-5696	95.3521	NM_001161407
NDFIP2	hsa-miR-576-5p	94.676	NM_001161407
NDFIP2	hsa-miR-153-5p	94.6074	NM_001161407
NDFIP2	hsa-miR-200a-5p	94.4024	NM_001161407
NDFIP2	hsa-miR-190a-3p	94.3846	NM_001161407
NDFIP2	hsa-miR-202-5p	94.2608	NM_001161407
NDFIP2	hsa-miR-5683	94.1465	NM_001161407
NDFIP2	hsa-miR-1468-3p	93.4979	NM_001161407
NDFIP2	hsa-miR-548f-5p	93.3553	NM_001161407
NDFIP2	hsa-miR-548g-5p	93.3553	NM_001161407
NDFIP2	hsa-miR-548aj-5p	93.3553	NM_001161407
NDFIP2	hsa-miR-548x-5p	93.3553	NM_001161407
NDFIP2	hsa-miR-4263	92.9725	NM_001161407
NDFIP2	hsa-miR-1277-5p	92.4821	NM_001161407
NDFIP2	hsa-miR-145-5p	91.8793	NM_001161407
NDFIP2	hsa-miR-5195-3p	91.8793	NM_001161407
NDFIP2	hsa-miR-1252-3p	91.749	NM_001161407
NDFIP2	hsa-miR-23b-3p	91.0327	NM_001161407
NDFIP2	hsa-miR-23c	91.0327	NM_001161407
NDFIP2	hsa-miR-23a-3p	91.0327	NM_001161407
NDFIP2	hsa-miR-4482-3p	90.9712	NM_001161407
NDFIP2	hsa-miR-3182	90.2119	NM_001161407
NDFIP2	hsa-miR-559	90.1304	NM_001161407
NDFIP2	hsa-miR-141-3p	89.524	NM_001161407
NDFIP2	hsa-miR-200a-3p	89.524	NM_001161407
NDFIP2	hsa-miR-3662	89.2613	NM_001161407
NDFIP2	hsa-miR-340-5p	88.7278	NM_001161407
NDFIP2	hsa-miR-875-3p	88.7109	NM_001161407
NDFIP2	hsa-miR-19a-3p	88.085	NM_001161407
NDFIP2	hsa-miR-19b-3p	88.085	NM_001161407
NDFIP2	hsa-miR-4799-5p	87.845	NM_001161407
NDFIP2	hsa-miR-6867-5p	87.5169	NM_001161407
NDFIP2	hsa-miR-552-5p	87.0615	NM_001161407
NDFIP2	hsa-miR-548i	86.3751	NM_001161407
NDFIP2	hsa-miR-548y	86.3751	NM_001161407
NDFIP2	hsa-miR-548a-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ak	86.3751	NM_001161407
NDFIP2	hsa-miR-548j-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548as-5p	86.3751	NM_001161407
NDFIP2	hsa-miR-548ae-5p	86.3751	NM_001161407

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Motifs and transcription factors (TFs) regulating NDFIP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDFIP2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NDFIP2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
NDFIP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NDFIP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NDFIP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
NDFIP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NDFIP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NDFIP2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
NDFIP2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
NDFIP2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
NDFIP2	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
NDFIP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NDFIP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."