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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NDEL1

Summary for NDEL1

Gene information	Gene symbol	NDEL1
	Ensembl ID	ENSG00000166579
	Entrez ID	81565
	Gene name	nudE neurodevelopment protein 1 like 1
	Synonyms	MITAP1\|NDE1L1\|NDE2\|NUDEL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NDEL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.995492	1.05e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.258591	8.18e-33

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Expression of NDEL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDEL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDEL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDEL1	hsa-miR-4676-5p	97.5425	NM_001025579
NDEL1	hsa-miR-575	97.5425	NM_001025579
NDEL1	hsa-miR-4427	95.276	NM_001025579
NDEL1	hsa-miR-107	93.731	NM_001025579
NDEL1	hsa-miR-103a-3p	93.731	NM_001025579
NDEL1	hsa-miR-4743-3p	93.7111	NM_001025579
NDEL1	hsa-miR-4677-3p	93.5162	NM_001025579
NDEL1	hsa-miR-3692-3p	93.1034	NM_030808
NDEL1	hsa-miR-4680-3p	92.8072	NM_001025579
NDEL1	hsa-miR-4652-3p	92.4172	NM_001025579
NDEL1	hsa-miR-5187-3p	91.9954	NM_001025579
NDEL1	hsa-miR-4679	91.7961	NM_001025579
NDEL1	hsa-miR-30c-5p	91.1216	NM_001025579
NDEL1	hsa-miR-30e-5p	91.1216	NM_001025579
NDEL1	hsa-miR-30d-5p	91.1216	NM_001025579
NDEL1	hsa-miR-30b-5p	91.1216	NM_001025579
NDEL1	hsa-miR-30a-5p	91.1216	NM_001025579
NDEL1	hsa-miR-6783-3p	89.9037	NM_001025579
NDEL1	hsa-miR-1343-3p	89.9037	NM_001025579
NDEL1	hsa-miR-6846-5p	89.4668	NM_030808
NDEL1	hsa-miR-6848-5p	89.4668	NM_030808
NDEL1	hsa-miR-5197-3p	88.2382	NM_001025579
NDEL1	hsa-miR-3927-5p	86.6951	NM_001025579
NDEL1	hsa-miR-186-5p	85.7546	NM_001025579
NDEL1	hsa-miR-4285	84.936	NM_030808
NDEL1	hsa-miR-6721-5p	83.6239	NM_030808
NDEL1	hsa-miR-378a-5p	81.456	NM_001025579
NDEL1	hsa-miR-20b-5p	80.6684	NM_030808
NDEL1	hsa-miR-106b-5p	80.6684	NM_030808
NDEL1	hsa-miR-20a-5p	80.6684	NM_030808
NDEL1	hsa-miR-17-5p	80.6684	NM_030808
NDEL1	hsa-miR-526b-3p	80.6684	NM_030808
NDEL1	hsa-miR-519d-3p	80.6684	NM_030808
NDEL1	hsa-miR-93-5p	80.6684	NM_030808
NDEL1	hsa-miR-106a-5p	80.6684	NM_030808
NDEL1	hsa-miR-11181-3p	80.0111	NM_001025579

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Motifs and transcription factors (TFs) regulating NDEL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDEL1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NDEL1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NDEL1	transfac_pro__M07387	ZBTB7A (directAnnotation).
NDEL1	transfac_pro__M07436	WT1 (directAnnotation).
NDEL1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NDEL1	transfac_pro__M00716	ZBTB14 (directAnnotation).
NDEL1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NDEL1	hdpi__HIP2	UBE2K (directAnnotation).
NDEL1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NDEL1	transfac_pro__M04893	TAF1 (directAnnotation).
NDEL1	transfac_pro__M03876	ZBTB33 (directAnnotation).
NDEL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NDEL1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
NDEL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NDEL1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NDEL1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
NDEL1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
NDEL1	transfac_pro__M01861	ATF1 (directAnnotation).
NDEL1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
NDEL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NDEL1	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
NDEL1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
NDEL1	transfac_public__M00039	CREB1 (directAnnotation).
NDEL1	transfac_public__M00040	ATF2 (directAnnotation).
NDEL1	transfac_pro__M08803	CREM (directAnnotation).
NDEL1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
NDEL1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
NDEL1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NDEL1	transfac_pro__M02089	E2F3 (directAnnotation).
NDEL1	hdpi__NRL	NRL (directAnnotation).
NDEL1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NDEL1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NDEL1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NDEL1	transfac_pro__M01199	TRIM28 (directAnnotation).
NDEL1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NDEL1	transfac_pro__M07329	SP7 (directAnnotation).
NDEL1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
NDEL1	cisbp__M07938	E2F1 (directAnnotation).
NDEL1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
NDEL1	transfac_pro__M01253	CNOT3 (directAnnotation).
NDEL1	transfac_pro__M07310	SP5 (directAnnotation).
NDEL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."