Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: NCS1

Summary for NCS1

Gene information	Gene symbol	NCS1
	Ensembl ID	ENSG00000107130
	Entrez ID	23413
	Gene name	neuronal calcium sensor 1
	Synonyms	FREQ\|NCS-1
	Gene type	protein_coding
	UniProtAcc	P62166

Top

Dataset with differentially expressed gene: NCS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.256743	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.365077	4.61e-22
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.422159	0.00e+00

Top

Expression of NCS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to NCS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating NCS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCS1	hsa-miR-5196-3p	97.5703	NM_001128826
NCS1	hsa-miR-2467-3p	92.9161	NM_001128826
NCS1	hsa-miR-6815-3p	91.6063	NM_001128826
NCS1	hsa-miR-4492	91.5988	NM_001128826
NCS1	hsa-miR-9851-5p	88.3041	NM_001128826
NCS1	hsa-miR-3184-5p	87.9892	NM_001128826
NCS1	hsa-miR-423-5p	87.9892	NM_001128826
NCS1	hsa-miR-10394-5p	87.8835	NM_001128826
NCS1	hsa-miR-650	87.7644	NM_001128826
NCS1	hsa-miR-95-5p	87.3687	NM_001128826
NCS1	hsa-miR-12123	86.5855	NM_001128826
NCS1	hsa-miR-3612	86.3684	NM_001128826
NCS1	hsa-miR-429	86.3663	NM_001128826
NCS1	hsa-miR-200c-3p	86.3663	NM_001128826
NCS1	hsa-miR-200b-3p	86.3663	NM_001128826
NCS1	hsa-miR-1286	85.9514	NM_001128826
NCS1	hsa-miR-6165	85.3474	NM_001128826
NCS1	hsa-miR-938	85.2184	NM_001128826
NCS1	hsa-miR-4498	85.2177	NM_001128826
NCS1	hsa-miR-4505	85.1878	NM_001128826
NCS1	hsa-miR-4722-5p	85.1288	NM_001128826
NCS1	hsa-miR-1205	84.9811	NM_001128826
NCS1	hsa-miR-5787	84.6172	NM_001128826
NCS1	hsa-miR-664a-3p	84.3239	NM_001128826
NCS1	hsa-miR-16-5p	83.7872	NM_001128826
NCS1	hsa-miR-6838-5p	83.7872	NM_001128826
NCS1	hsa-miR-15a-5p	83.7872	NM_001128826
NCS1	hsa-miR-195-5p	83.7872	NM_001128826
NCS1	hsa-miR-15b-5p	83.7872	NM_001128826
NCS1	hsa-miR-6756-5p	82.7433	NM_001128826
NCS1	hsa-miR-6882-3p	81.8689	NM_001128826
NCS1	hsa-miR-190a-3p	81.3861	NM_001128826
NCS1	hsa-miR-6878-3p	80.8464	NM_001128826
NCS1	hsa-miR-4272	80.6955	NM_001128826
NCS1	hsa-miR-497-5p	80.274	NM_001128826
NCS1	hsa-miR-424-5p	80.274	NM_001128826
NCS1	hsa-miR-6766-5p	80.27	NM_001128826

Page: 1

Top

Motifs and transcription factors (TFs) regulating NCS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCS1	transfac_pro__M06071	ZNF814 (directAnnotation).
NCS1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NCS1	cisbp__M08198	ELF1 (directAnnotation).
NCS1	transfac_pro__M00652	NRF1 (directAnnotation).
NCS1	transfac_pro__M05791	ZNF517 (directAnnotation).
NCS1	transfac_pro__M01253	CNOT3 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
NCS1	"Calcium citrate"	DB11093	small molecule
NCS1	"Calcium phosphate dihydrate"	DB14481	small molecule
NCS1	"Calcium Phosphate"	DB11348	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."