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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCEH1

Summary for NCEH1

Gene information	Gene symbol	NCEH1
	Ensembl ID	ENSG00000144959
	Entrez ID	57552
	Gene name	neutral cholesterol ester hydrolase 1
	Synonyms	AADACL1\|KIAA1363\|NCEH
	Gene type	protein_coding
	UniProtAcc	Q6PIU2

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Dataset with differentially expressed gene: NCEH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.434276	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.292861	5.11e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.743436	0.00e+00

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Expression of NCEH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCEH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCEH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCEH1	hsa-miR-3163	98.7457	NM_001146276
NCEH1	hsa-miR-335-3p	97.731	NM_001146276
NCEH1	hsa-miR-576-5p	97.1329	NM_001146276
NCEH1	hsa-miR-153-5p	97.0169	NM_001146276
NCEH1	hsa-miR-664b-3p	97.0078	NM_001146276
NCEH1	hsa-miR-579-3p	97.0078	NM_001146276
NCEH1	hsa-miR-1297	92.5984	NM_001146276
NCEH1	hsa-miR-7158-3p	92.215	NM_001146276
NCEH1	hsa-miR-4496	90.9304	NM_001146276
NCEH1	hsa-miR-26b-5p	89.0047	NM_001146276
NCEH1	hsa-miR-26a-5p	89.0047	NM_001146276
NCEH1	hsa-miR-4465	88.8284	NM_001146276
NCEH1	hsa-miR-33a-3p	88.4358	NM_001146276
NCEH1	hsa-miR-557	88.0032	NM_001146276
NCEH1	hsa-miR-7106-5p	87.9792	NM_001146276
NCEH1	hsa-miR-507	87.6762	NM_001146276
NCEH1	hsa-miR-4784	87.4069	NM_001146276
NCEH1	hsa-miR-3150b-3p	87.4069	NM_001146276
NCEH1	hsa-miR-449a	86.2356	NM_001146276
NCEH1	hsa-miR-34a-5p	86.2356	NM_001146276
NCEH1	hsa-miR-518f-5p	85.6409	NM_001146276
NCEH1	hsa-miR-519a-5p	85.6409	NM_001146276
NCEH1	hsa-miR-518e-5p	85.6409	NM_001146276
NCEH1	hsa-miR-522-5p	85.6409	NM_001146276
NCEH1	hsa-miR-519c-5p	85.6409	NM_001146276
NCEH1	hsa-miR-526a-5p	85.6409	NM_001146276
NCEH1	hsa-miR-519b-5p	85.6409	NM_001146276
NCEH1	hsa-miR-518d-5p	85.6409	NM_001146276
NCEH1	hsa-miR-523-5p	85.6409	NM_001146276
NCEH1	hsa-miR-520c-5p	85.6409	NM_001146276
NCEH1	hsa-miR-34c-5p	85.3681	NM_001146276
NCEH1	hsa-miR-449b-5p	85.3681	NM_001146276
NCEH1	hsa-miR-95-5p	84.2216	NM_001146276
NCEH1	hsa-miR-3689c	83.1997	NM_001146276
NCEH1	hsa-miR-30b-3p	83.1997	NM_001146276
NCEH1	hsa-miR-3689a-3p	83.1997	NM_001146276
NCEH1	hsa-miR-3689b-3p	83.1997	NM_001146276
NCEH1	hsa-miR-6779-5p	83.1997	NM_001146276
NCEH1	hsa-miR-6780a-5p	83.1997	NM_001146276
NCEH1	hsa-miR-1273h-5p	83.1997	NM_001146276
NCEH1	hsa-miR-101-5p	82.1713	NM_001146276
NCEH1	hsa-miR-3133	81.6328	NM_001146276
NCEH1	hsa-miR-5696	81.2144	NM_001146276
NCEH1	hsa-miR-5697	80.3297	NM_001146276
NCEH1	hsa-miR-4799-5p	80.1929	NM_001146276

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Motifs and transcription factors (TFs) regulating NCEH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCEH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NCEH1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
NCEH1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
NCEH1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
NCEH1	tfdimers__MD00475	FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; ZNF333 (directAnnotation).
NCEH1	transfac_pro__M05521	ZNF398 (directAnnotation).
NCEH1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."