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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCBP2

Summary for NCBP2

Gene information	Gene symbol	NCBP2
	Ensembl ID	ENSG00000114503
	Entrez ID	22916
	Gene name	nuclear cap binding protein subunit 2
	Synonyms	Cbc2\|CBP20\|NIP1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NCBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.391474	8.90e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.447614	7.90e-32
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.262125	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.31663	9.21e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.581942	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.289111	0.00e+00

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Expression of NCBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCBP2	hsa-miR-4771	95.4092	NM_001042540
NCBP2	hsa-miR-4267	91.6972	NM_007362
NCBP2	hsa-miR-6888-3p	88.9295	NM_007362
NCBP2	hsa-miR-499b-5p	87.6148	NM_001042540
NCBP2	hsa-miR-4682	87.0545	NM_007362
NCBP2	hsa-miR-181b-3p	86.4998	NM_007362
NCBP2	hsa-miR-181b-2-3p	86.4998	NM_007362
NCBP2	hsa-miR-186-5p	86.187	NM_007362
NCBP2	hsa-miR-4330	85.9011	NM_007362
NCBP2	hsa-miR-548an	85.5977	NM_001042540
NCBP2	hsa-miR-3915	85.5439	NM_007362
NCBP2	hsa-miR-1273h-3p	84.6708	NM_001042540
NCBP2	hsa-miR-1252-3p	82.9886	NM_001042540
NCBP2	hsa-miR-1252-5p	82.9732	NM_007362
NCBP2	hsa-miR-4420	82.5027	NM_007362
NCBP2	hsa-miR-1972	82.0026	NM_007362
NCBP2	hsa-miR-4432	81.9283	NM_007362
NCBP2	hsa-miR-548az-5p	80.9221	NM_001042540
NCBP2	hsa-miR-548t-5p	80.9221	NM_001042540
NCBP2	hsa-miR-12127	80.8075	NM_007362

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Motifs and transcription factors (TFs) regulating NCBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCBP2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
NCBP2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
NCBP2	transfac_pro__M04862	NRF1 (directAnnotation).
NCBP2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
NCBP2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
NCBP2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NCBP2	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
NCBP2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
NCBP2	jaspar__MA0748.2	YY2 (directAnnotation).
NCBP2	transfac_pro__M06173	ZNF85 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."