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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCAPH2

Summary for NCAPH2

Gene information	Gene symbol	NCAPH2
	Ensembl ID	ENSG00000025770
	Entrez ID	29781
	Gene name	non-SMC condensin II complex subunit H2
	Synonyms	384D8-2\|CAP-H2\|hCAP-H2
	Gene type	protein_coding
	UniProtAcc	Q6IBW4

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Dataset with differentially expressed gene: NCAPH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.425261	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.387346	0.00e+00

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Expression of NCAPH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCAPH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCAPH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCAPH2	hsa-miR-6867-5p	95.9061	NM_152299
NCAPH2	hsa-miR-3658	92.5945	NM_152299
NCAPH2	hsa-miR-4726-3p	90.9339	NM_152299
NCAPH2	hsa-miR-4711-5p	88.1233	NM_014551
NCAPH2	hsa-miR-3691-5p	87.7573	NM_152299
NCAPH2	hsa-miR-4303	86.8987	NM_152299
NCAPH2	hsa-miR-6794-5p	86.6865	NM_152299
NCAPH2	hsa-miR-4716-3p	86.6865	NM_152299
NCAPH2	hsa-miR-92b-3p	84.8019	NM_001185011
NCAPH2	hsa-miR-32-5p	84.8019	NM_001185011
NCAPH2	hsa-miR-92a-3p	84.8019	NM_001185011
NCAPH2	hsa-miR-874-5p	83.8438	NM_001185011
NCAPH2	hsa-miR-137-3p	83.0995	NM_001185011
NCAPH2	hsa-miR-25-3p	82.4857	NM_001185011
NCAPH2	hsa-miR-363-3p	82.4857	NM_001185011
NCAPH2	hsa-miR-367-3p	82.4857	NM_001185011

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Motifs and transcription factors (TFs) regulating NCAPH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCAPH2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."