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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NBN

Summary for NBN

Gene information	Gene symbol	NBN
	Ensembl ID	ENSG00000104320
	Entrez ID	4683
	Gene name	nibrin
	Synonyms	AT-V1\|AT-V2\|ATV\|NBS\|NBS1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NBN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.329976	7.39e-23
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.421091	5.42e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.487325	8.37e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.513111	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.29936	0.00e+00

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Expression of NBN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NBN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NBN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NBN	hsa-miR-561-3p	98.337	NM_001024688
NBN	hsa-miR-4719	93.0362	NM_001024688
NBN	hsa-miR-8065	92.6476	NM_001024688
NBN	hsa-miR-6074	92.1116	NM_001024688
NBN	hsa-miR-625-5p	90.5692	NM_001024688
NBN	hsa-miR-4306	89.9042	NM_001024688
NBN	hsa-miR-6815-3p	88.879	NM_001024688
NBN	hsa-miR-337-3p	87.7929	NM_001024688
NBN	hsa-miR-6758-3p	87.6514	NM_001024688
NBN	hsa-miR-6809-5p	87.5062	NM_001024688
NBN	hsa-miR-142-5p	87.0902	NM_001024688
NBN	hsa-miR-5590-3p	87.0902	NM_001024688
NBN	hsa-miR-6862-5p	86.8181	NM_001024688
NBN	hsa-miR-641	86.666	NM_001024688
NBN	hsa-miR-3617-5p	86.666	NM_001024688
NBN	hsa-miR-6124	86.1902	NM_001024688
NBN	hsa-miR-185-5p	85.9481	NM_001024688
NBN	hsa-miR-4644	85.9481	NM_001024688
NBN	hsa-miR-1275	84.3131	NM_001024688
NBN	hsa-miR-2113	83.5201	NM_001024688
NBN	hsa-miR-5704	83.2927	NM_001024688
NBN	hsa-miR-138-1-3p	83.0335	NM_001024688
NBN	hsa-miR-3170	82.4846	NM_001024688
NBN	hsa-miR-4308	82.3371	NM_001024688
NBN	hsa-miR-4685-3p	82.2283	NM_001024688
NBN	hsa-miR-4287	82.2283	NM_001024688
NBN	hsa-miR-3927-3p	82.18	NM_001024688
NBN	hsa-miR-6831-5p	82.18	NM_001024688
NBN	hsa-miR-4650-3p	82.0772	NM_001024688
NBN	hsa-miR-548aa	82.0011	NM_001024688
NBN	hsa-miR-548t-3p	82.0011	NM_001024688
NBN	hsa-miR-548ap-3p	82.0011	NM_001024688
NBN	hsa-miR-7159-3p	80.9026	NM_001024688
NBN	hsa-miR-6855-5p	80.8614	NM_001024688

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Motifs and transcription factors (TFs) regulating NBN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NBN	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NBN	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
NBN	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NBN	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NBN	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NBN	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
NBN	transfac_pro__M04950	EGR1 (directAnnotation).
NBN	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NBN	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NBN	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
NBN	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NBN	transfac_pro__M00652	NRF1 (directAnnotation).
NBN	transfac_pro__M04866	HDAC2 (directAnnotation).
NBN	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
NBN	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
NBN	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
NBN	jaspar__MA1684.1	FOXN1 (inferredBy_Orthology).
NBN	transfac_pro__M06741	ZNF70 (directAnnotation).
NBN	transfac_pro__M06556	ZNF383 (directAnnotation).
NBN	taipale_tf_pairs__GCM1_FOXI1_NNGTMAATANGGGYR_CAP	FOXI1; GCM1 (directAnnotation).
NBN	transfac_pro__M05991	ZFP64 (directAnnotation).
NBN	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
NBN	transfac_pro__M06012	ZNF586 (directAnnotation).
NBN	transfac_pro__M01239	RELA (directAnnotation).
NBN	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
NBN	taipale_tf_pairs__ETV2_GSC2_RCCGGANNNNNNNNNTAATCCN_CAP_repr	ETV2; GSC2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."