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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NALCN

Summary for NALCN

Gene information	Gene symbol	NALCN
	Ensembl ID	ENSG00000102452
	Entrez ID	259232
	Gene name	sodium leak channel, non-selective
	Synonyms	bA430M15.1\|CanIon\|VGCNL1
	Gene type	protein_coding
	UniProtAcc	Q8IZF0

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Dataset with differentially expressed gene: NALCN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.421755	0.00e+00

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Expression of NALCN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NALCN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NALCN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NALCN	hsa-miR-555	95.7713	NM_052867
NALCN	hsa-miR-3121-3p	95.0279	NM_052867
NALCN	hsa-miR-581	93.9535	NM_052867
NALCN	hsa-miR-1288-5p	90.8026	NM_052867
NALCN	hsa-miR-587	88.0747	NM_052867
NALCN	hsa-miR-20b-3p	87.6238	NM_052867
NALCN	hsa-miR-551b-5p	87.5326	NM_052867
NALCN	hsa-miR-2276-5p	87.4883	NM_052867
NALCN	hsa-miR-3908	86.9588	NM_052867
NALCN	hsa-let-7c-3p	86.934	NM_052867
NALCN	hsa-miR-15b-3p	86.7624	NM_052867
NALCN	hsa-miR-153-5p	86.658	NM_052867
NALCN	hsa-miR-5692a	86.367	NM_052867
NALCN	hsa-miR-8055	85.5304	NM_052867
NALCN	hsa-miR-12119	84.9658	NM_052867
NALCN	hsa-miR-10523-5p	84.8854	NM_052867
NALCN	hsa-miR-651-3p	84.8636	NM_052867
NALCN	hsa-miR-6739-5p	84.5897	NM_052867
NALCN	hsa-miR-6733-5p	84.5897	NM_052867
NALCN	hsa-miR-576-5p	84.1412	NM_052867
NALCN	hsa-miR-3942-3p	83.9879	NM_052867
NALCN	hsa-miR-3148	83.554	NM_052867
NALCN	hsa-miR-588	83.0738	NM_052867
NALCN	hsa-miR-4701-5p	83.0738	NM_052867
NALCN	hsa-miR-4786-3p	82.732	NM_052867
NALCN	hsa-miR-5100	81.5808	NM_052867
NALCN	hsa-miR-3976	81.0256	NM_052867
NALCN	hsa-miR-3153	80.7214	NM_052867

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Motifs and transcription factors (TFs) regulating NALCN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NALCN	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
NALCN	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NALCN	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NALCN	transfac_pro__M04826	EP300 (directAnnotation).
NALCN	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NALCN	transfac_pro__M00652	NRF1 (directAnnotation).
NALCN	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NALCN	transfac_pro__M04866	HDAC2 (directAnnotation).
NALCN	jaspar__MA1122.1	TFDP1 (directAnnotation).
NALCN	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NALCN	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."