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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NADK2

Summary for NADK2

Gene information	Gene symbol	NADK2
	Ensembl ID	ENSG00000152620
	Entrez ID	133686
	Gene name	NAD kinase 2, mitochondrial
	Synonyms	C5orf33\|FLJ30596\|MNADK\|NADKD1
	Gene type	protein_coding
	UniProtAcc	Q4G0N4

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Dataset with differentially expressed gene: NADK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.30698	3.15e-26
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.270372	1.30e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.396277	2.31e-35

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Expression of NADK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NADK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NADK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NADK2	hsa-miR-3613-3p	99.2877	NM_001085411
NADK2	hsa-miR-607	99.2403	NM_001085411
NADK2	hsa-miR-8063	98.1593	NM_001085411
NADK2	hsa-miR-4698	96.8684	NM_001085411
NADK2	hsa-miR-5009-3p	96.0137	NM_001085411
NADK2	hsa-miR-3143	95.64	NM_001085411
NADK2	hsa-miR-543	95.0322	NM_001085411
NADK2	hsa-miR-182-5p	94.8685	NM_001085411
NADK2	hsa-miR-3620-3p	94.8408	NM_001085411
NADK2	hsa-miR-5680	94.1693	NM_001085411
NADK2	hsa-miR-590-3p	93.2388	NM_001085411
NADK2	hsa-miR-95-5p	92.6397	NM_001085411
NADK2	hsa-miR-409-5p	92.2589	NM_001085411
NADK2	hsa-let-7f-2-3p	92.1934	NM_001085411
NADK2	hsa-miR-3658	91.909	NM_001085411
NADK2	hsa-let-7a-3p	90.9122	NM_001085411
NADK2	hsa-miR-1185-2-3p	89.6781	NM_001085411
NADK2	hsa-miR-1185-1-3p	89.6781	NM_001085411
NADK2	hsa-miR-98-3p	89.2106	NM_001085411
NADK2	hsa-let-7b-3p	89.2106	NM_001085411
NADK2	hsa-let-7f-1-3p	89.2106	NM_001085411
NADK2	hsa-miR-494-3p	89.1329	NM_001085411
NADK2	hsa-miR-3191-5p	87.8764	NM_001085411
NADK2	hsa-miR-135b-5p	87.76	NM_001085411
NADK2	hsa-miR-135a-5p	87.76	NM_001085411
NADK2	hsa-miR-3163	86.9831	NM_001085411
NADK2	hsa-miR-4432	86.038	NM_001085411
NADK2	hsa-miR-4775	85.9254	NM_001085411
NADK2	hsa-miR-3065-3p	85.674	NM_001085411
NADK2	hsa-miR-3074-3p	85.2545	NM_001085411
NADK2	hsa-miR-4266	85.2098	NM_001085411
NADK2	hsa-miR-383-3p	84.897	NM_001085411
NADK2	hsa-miR-5571-5p	84.4717	NM_001085411
NADK2	hsa-miR-4691-5p	84.0455	NM_001085411
NADK2	hsa-miR-6792-3p	84.0455	NM_001085411
NADK2	hsa-miR-2110	83.5378	NM_001085411
NADK2	hsa-miR-570-3p	82.1934	NM_001085411
NADK2	hsa-miR-551b-5p	81.6024	NM_001085411
NADK2	hsa-miR-625-3p	81.5592	NM_001085411
NADK2	hsa-miR-12136	80.8794	NM_001085411
NADK2	hsa-miR-4540	80.0395	NM_001085411

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Motifs and transcription factors (TFs) regulating NADK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NADK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
NADK2	tfdimers__MD00038	TFAP2C (directAnnotation).
NADK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NADK2	metacluster_7.13	ZFX (directAnnotation).
NADK2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NADK2	cisbp__M00968	MTF2 (directAnnotation).
NADK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NADK2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NADK2	cisbp__M00341	PAX6 (directAnnotation).
NADK2	metacluster_198.3	ZFP64 (directAnnotation).
NADK2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NADK2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NADK2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
NADK2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NADK2	cisbp__M00788	ZFY (inferredBy_Orthology).
NADK2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NADK2	metacluster_175.1	ZNF283 (directAnnotation).
NADK2	hdpi__ZNF304	ZNF304 (directAnnotation).
NADK2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NADK2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NADK2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NADK2	transfac_pro__M01199	TRIM28 (directAnnotation).
NADK2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
NADK2	metacluster_151.2	ZNF23 (directAnnotation).
NADK2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NADK2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NADK2	transfac_pro__M03806	ZBTB7C (directAnnotation).
NADK2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NADK2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
NADK2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
NADK2	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
NADK2	jaspar__MA0502.2	NFYB (directAnnotation).
NADK2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
NADK2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NADK2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
NADK2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
NADK2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
NADK2	cisbp__M00249	WT1 (directAnnotation).
NADK2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
NADK2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NADK2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NADK2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
NADK2	transfac_pro__M04950	EGR1 (directAnnotation).
NADK2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."