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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NACC1

Summary for NACC1

Gene information	Gene symbol	NACC1
	Ensembl ID	ENSG00000160877
	Entrez ID	112939
	Gene name	nucleus accumbens associated 1
	Synonyms	BEND8\|BTBD14B\|BTBD30\|NAC-1\|NAC1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NACC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.57531	1.10e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.322412	4.86e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.308797	0.00e+00

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Expression of NACC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NACC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NACC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NACC1	hsa-miR-6825-5p	99.9327	NM_052876
NACC1	hsa-miR-4728-5p	99.5287	NM_052876
NACC1	hsa-miR-6785-5p	99.5287	NM_052876
NACC1	hsa-miR-149-3p	99.4475	NM_052876
NACC1	hsa-miR-6867-5p	99.3462	NM_052876
NACC1	hsa-miR-6883-5p	99.2851	NM_052876
NACC1	hsa-miR-6852-5p	96.6723	NM_052876
NACC1	hsa-miR-4447	96.125	NM_052876
NACC1	hsa-miR-92a-2-5p	96.092	NM_052876
NACC1	hsa-miR-939-5p	95.8377	NM_052876
NACC1	hsa-miR-1343-5p	95.8377	NM_052876
NACC1	hsa-miR-6846-5p	94.2456	NM_052876
NACC1	hsa-miR-6848-5p	94.2456	NM_052876
NACC1	hsa-miR-3175	93.5687	NM_052876
NACC1	hsa-miR-8485	93.458	NM_052876
NACC1	hsa-miR-3129-5p	93.181	NM_052876
NACC1	hsa-miR-199a-3p	93.181	NM_052876
NACC1	hsa-miR-199b-3p	93.181	NM_052876
NACC1	hsa-miR-218-5p	92.0743	NM_052876
NACC1	hsa-miR-3150a-3p	91.6331	NM_052876
NACC1	hsa-miR-6763-5p	91.6331	NM_052876
NACC1	hsa-miR-7106-5p	90.5691	NM_052876
NACC1	hsa-miR-1207-5p	90.1993	NM_052876
NACC1	hsa-miR-361-3p	89.9806	NM_052876
NACC1	hsa-miR-4763-3p	87.9798	NM_052876
NACC1	hsa-miR-4472	87.6671	NM_052876
NACC1	hsa-miR-4651	86.8872	NM_052876
NACC1	hsa-miR-608	86.8872	NM_052876
NACC1	hsa-miR-2355-5p	86.5836	NM_052876
NACC1	hsa-miR-6828-5p	84.8682	NM_052876
NACC1	hsa-miR-600	82.9826	NM_052876
NACC1	hsa-miR-6810-3p	80.6421	NM_052876
NACC1	hsa-miR-423-5p	80.0916	NM_052876
NACC1	hsa-miR-3184-5p	80.0916	NM_052876

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Motifs and transcription factors (TFs) regulating NACC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NACC1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
NACC1	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."