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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NAALADL2

Summary for NAALADL2

Gene information	Gene symbol	NAALADL2
	Ensembl ID	ENSG00000177694
	Entrez ID	254827
	Gene name	N-acetylated alpha-linked acidic dipeptidase like 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NAALADL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.537174	0.00e+00

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Expression of NAALADL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NAALADL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NAALADL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NAALADL2	hsa-miR-335-3p	98.955	NM_207015
NAALADL2	hsa-miR-452-3p	97.7562	NM_207015
NAALADL2	hsa-miR-633	97.2817	NM_207015
NAALADL2	hsa-miR-4698	97.176	NM_207015
NAALADL2	hsa-miR-548aw	96.4172	NM_207015
NAALADL2	hsa-miR-548t-3p	94.9257	NM_207015
NAALADL2	hsa-miR-548aa	94.9257	NM_207015
NAALADL2	hsa-miR-548ap-3p	94.9257	NM_207015
NAALADL2	hsa-miR-543	94.8578	NM_207015
NAALADL2	hsa-miR-4262	94.6819	NM_207015
NAALADL2	hsa-miR-181a-5p	94.0476	NM_207015
NAALADL2	hsa-miR-181d-5p	94.0476	NM_207015
NAALADL2	hsa-miR-181b-5p	94.0476	NM_207015
NAALADL2	hsa-miR-181c-5p	94.0476	NM_207015
NAALADL2	hsa-miR-551b-5p	93.874	NM_207015
NAALADL2	hsa-miR-4649-3p	93.1595	NM_207015
NAALADL2	hsa-miR-3935	93.0999	NM_207015
NAALADL2	hsa-miR-664b-3p	92.9149	NM_207015
NAALADL2	hsa-miR-579-3p	92.9149	NM_207015
NAALADL2	hsa-miR-12136	92.4799	NM_207015
NAALADL2	hsa-miR-6739-3p	92.457	NM_207015
NAALADL2	hsa-miR-5696	92.3937	NM_207015
NAALADL2	hsa-miR-4684-3p	92.3595	NM_207015
NAALADL2	hsa-miR-19a-3p	92.3455	NM_207015
NAALADL2	hsa-miR-19b-3p	92.3455	NM_207015
NAALADL2	hsa-miR-495-3p	92.1755	NM_207015
NAALADL2	hsa-miR-5688	92.0047	NM_207015
NAALADL2	hsa-miR-892c-5p	91.9966	NM_207015
NAALADL2	hsa-miR-1275	91.907	NM_207015
NAALADL2	hsa-miR-607	91.8466	NM_207015
NAALADL2	hsa-miR-527	91.3105	NM_207015
NAALADL2	hsa-miR-518a-5p	91.3105	NM_207015
NAALADL2	hsa-miR-3934-3p	90.1872	NM_207015
NAALADL2	hsa-miR-30c-5p	90.1769	NM_207015
NAALADL2	hsa-miR-30a-5p	90.1769	NM_207015
NAALADL2	hsa-miR-30e-5p	90.1769	NM_207015
NAALADL2	hsa-miR-30d-5p	90.1769	NM_207015
NAALADL2	hsa-miR-30b-5p	90.1769	NM_207015
NAALADL2	hsa-miR-5692a	90.1376	NM_207015
NAALADL2	hsa-miR-32-3p	89.7276	NM_207015
NAALADL2	hsa-miR-4452	89.4712	NM_207015
NAALADL2	hsa-miR-382-5p	89.3359	NM_207015
NAALADL2	hsa-miR-302f	89.085	NM_207015
NAALADL2	hsa-miR-450a-2-3p	88.908	NM_207015
NAALADL2	hsa-miR-548n	88.73	NM_207015
NAALADL2	hsa-miR-1290	88.5388	NM_207015
NAALADL2	hsa-miR-3074-3p	87.9176	NM_207015
NAALADL2	hsa-miR-4665-5p	86.9775	NM_207015
NAALADL2	hsa-miR-4666a-3p	86.232	NM_207015
NAALADL2	hsa-miR-2110	86.0705	NM_207015

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Motifs and transcription factors (TFs) regulating NAALADL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."