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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: N4BP2L1

Summary for N4BP2L1

Gene information	Gene symbol	N4BP2L1
	Ensembl ID	ENSG00000139597
	Entrez ID	90634
	Gene name	NEDD4 binding protein 2 like 1
	Synonyms	CG018
	Gene type	protein_coding
	UniProtAcc	Q5TBK1

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Dataset with differentially expressed gene: N4BP2L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.256661	0.00e+00

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Expression of N4BP2L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to N4BP2L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating N4BP2L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
N4BP2L1	hsa-miR-620	96.5359	NM_001079691
N4BP2L1	hsa-miR-1270	96.5359	NM_001079691
N4BP2L1	hsa-miR-3119	96.4529	NM_001079691
N4BP2L1	hsa-miR-5011-5p	93.9136	NM_052818
N4BP2L1	hsa-miR-498-3p	93.8966	NM_001079691
N4BP2L1	hsa-miR-4720-5p	93.2368	NM_001079691
N4BP2L1	hsa-miR-4799-3p	93.2368	NM_001079691
N4BP2L1	hsa-miR-5588-5p	93.2368	NM_001079691
N4BP2L1	hsa-miR-4683	92.9164	NM_001079691
N4BP2L1	hsa-miR-6757-3p	91.8932	NM_001079691
N4BP2L1	hsa-miR-4774-5p	91.6543	NM_001286460
N4BP2L1	hsa-miR-6509-5p	91.3824	NM_001286460
N4BP2L1	hsa-miR-1276	90.7867	NM_001286460
N4BP2L1	hsa-miR-3126-3p	89.9309	NM_001079691
N4BP2L1	hsa-miR-767-5p	89.3834	NM_001079691
N4BP2L1	hsa-miR-4711-5p	88.5898	NM_052818
N4BP2L1	hsa-miR-342-3p	88.455	NM_052818
N4BP2L1	hsa-miR-548a-3p	87.9099	NM_052818
N4BP2L1	hsa-miR-548f-3p	87.9099	NM_052818
N4BP2L1	hsa-miR-548ar-3p	87.9099	NM_052818
N4BP2L1	hsa-miR-548az-3p	87.9099	NM_052818
N4BP2L1	hsa-miR-548bc	87.9099	NM_052818
N4BP2L1	hsa-miR-548e-3p	87.9099	NM_052818
N4BP2L1	hsa-miR-582-3p	87.5934	NM_001286460
N4BP2L1	hsa-miR-548s	87.5024	NM_001286460
N4BP2L1	hsa-miR-7-1-3p	87.3963	NM_052818
N4BP2L1	hsa-miR-7-2-3p	87.3963	NM_052818
N4BP2L1	hsa-miR-190a-3p	86.7574	NM_052818
N4BP2L1	hsa-miR-4699-3p	85.2328	NM_001079691
N4BP2L1	hsa-miR-1256	84.6939	NM_001079691
N4BP2L1	hsa-miR-376a-5p	84.5934	NM_001286460
N4BP2L1	hsa-miR-29c-3p	84.1265	NM_001079691
N4BP2L1	hsa-miR-29b-3p	84.1265	NM_001079691
N4BP2L1	hsa-miR-29a-3p	84.1265	NM_001079691
N4BP2L1	hsa-miR-6501-3p	82.9694	NM_052818
N4BP2L1	hsa-miR-548e-5p	82.9212	NM_001286460
N4BP2L1	hsa-miR-888-5p	82.5707	NM_052818
N4BP2L1	hsa-miR-5006-3p	81.6363	NM_001079691
N4BP2L1	hsa-miR-4755-5p	81.6363	NM_001079691
N4BP2L1	hsa-miR-6502-5p	80.9968	NM_001286460
N4BP2L1	hsa-miR-1301-5p	80.9968	NM_001286460
N4BP2L1	hsa-miR-651-3p	80.7234	NM_001079691
N4BP2L1	hsa-miR-6835-3p	80.5334	NM_001079691
N4BP2L1	hsa-miR-6762-3p	80.4335	NM_001286460
N4BP2L1	hsa-miR-4643	80.1801	NM_052818

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Motifs and transcription factors (TFs) regulating N4BP2L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
N4BP2L1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
N4BP2L1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
N4BP2L1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."