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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: N4BP1

Summary for N4BP1

Gene information	Gene symbol	N4BP1
	Ensembl ID	ENSG00000102921
	Entrez ID	9683
	Gene name	NEDD4 binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O75113

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Dataset with differentially expressed gene: N4BP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.266791	4.65e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.259395	0.00e+00

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Expression of N4BP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to N4BP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating N4BP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
N4BP1	hsa-miR-4514	98.8595	NM_153029
N4BP1	hsa-miR-4692	98.8595	NM_153029
N4BP1	hsa-miR-107	97.5689	NM_153029
N4BP1	hsa-miR-103a-3p	97.5689	NM_153029
N4BP1	hsa-miR-195-5p	96.3138	NM_153029
N4BP1	hsa-miR-16-5p	96.3138	NM_153029
N4BP1	hsa-miR-15b-5p	96.3138	NM_153029
N4BP1	hsa-miR-15a-5p	96.3138	NM_153029
N4BP1	hsa-miR-2467-3p	95.8485	NM_153029
N4BP1	hsa-miR-4524b-5p	95.7651	NM_153029
N4BP1	hsa-miR-4524a-5p	95.7651	NM_153029
N4BP1	hsa-miR-651-3p	95.514	NM_153029
N4BP1	hsa-miR-497-5p	95.4702	NM_153029
N4BP1	hsa-miR-424-5p	95.4702	NM_153029
N4BP1	hsa-miR-6838-5p	95.3842	NM_153029
N4BP1	hsa-miR-204-3p	93.141	NM_153029
N4BP1	hsa-miR-503-5p	93.0493	NM_153029
N4BP1	hsa-miR-4803	92.8182	NM_153029
N4BP1	hsa-miR-7106-5p	92.2944	NM_153029
N4BP1	hsa-miR-4646-5p	91.7128	NM_153029
N4BP1	hsa-miR-182-5p	91.1018	NM_153029
N4BP1	hsa-miR-10394-5p	91.0884	NM_153029
N4BP1	hsa-miR-190a-3p	91.0712	NM_153029
N4BP1	hsa-miR-646	90.8164	NM_153029
N4BP1	hsa-miR-4477b	90.7624	NM_153029
N4BP1	hsa-miR-6754-3p	90.3267	NM_153029
N4BP1	hsa-miR-6837-3p	90.0495	NM_153029
N4BP1	hsa-miR-3124-3p	89.986	NM_153029
N4BP1	hsa-miR-1205	88.164	NM_153029
N4BP1	hsa-miR-412-3p	87.8536	NM_153029
N4BP1	hsa-miR-3192-5p	86.5614	NM_153029
N4BP1	hsa-miR-216a-3p	86.437	NM_153029
N4BP1	hsa-miR-128-3p	86.437	NM_153029
N4BP1	hsa-miR-1910-3p	86.4142	NM_153029
N4BP1	hsa-miR-6127	86.1785	NM_153029
N4BP1	hsa-miR-3652	85.6647	NM_153029
N4BP1	hsa-miR-4430	85.6647	NM_153029
N4BP1	hsa-miR-1233-5p	85.6402	NM_153029
N4BP1	hsa-miR-6785-5p	85.3018	NM_153029
N4BP1	hsa-miR-4728-5p	85.3018	NM_153029
N4BP1	hsa-miR-23a-3p	84.596	NM_153029
N4BP1	hsa-miR-23c	84.596	NM_153029
N4BP1	hsa-miR-23b-3p	84.596	NM_153029
N4BP1	hsa-miR-129-1-3p	83.9561	NM_153029
N4BP1	hsa-miR-129-2-3p	83.9561	NM_153029
N4BP1	hsa-miR-6825-5p	83.6472	NM_153029
N4BP1	hsa-miR-6511a-5p	82.9949	NM_153029
N4BP1	hsa-miR-6879-5p	81.9266	NM_153029
N4BP1	hsa-miR-4436b-3p	81.9266	NM_153029
N4BP1	hsa-miR-6735-5p	81.9266	NM_153029

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Motifs and transcription factors (TFs) regulating N4BP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
N4BP1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
N4BP1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."