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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MZT1

Summary for MZT1

Gene information	Gene symbol	MZT1
	Ensembl ID	ENSG00000204899
	Entrez ID	440145
	Gene name	mitotic spindle organizing protein 1
	Synonyms	C13orf37\|FLJ21869\|LOC440145\|MGC150539\|MOZART1\|RP11-11C5.2
	Gene type	protein_coding
	UniProtAcc	Q08AG7

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Dataset with differentially expressed gene: MZT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.891927	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.250741	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.261785	2.81e-07
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.286057	1.40e-06
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.269273	0.00e+00

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Expression of MZT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MZT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MZT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MZT1	hsa-miR-4282	99.8823	NM_001071775
MZT1	hsa-miR-3613-3p	99.6165	NM_001071775
MZT1	hsa-miR-5692a	99.3956	NM_001071775
MZT1	hsa-miR-3658	98.6601	NM_001071775
MZT1	hsa-miR-12136	97.83	NM_001071775
MZT1	hsa-miR-6509-3p	96.375	NM_001071775
MZT1	hsa-miR-548n	96.3555	NM_001071775
MZT1	hsa-miR-4755-3p	94.335	NM_001071775
MZT1	hsa-miR-30c-5p	94.2048	NM_001071775
MZT1	hsa-miR-30e-5p	94.2048	NM_001071775
MZT1	hsa-miR-30b-5p	94.2048	NM_001071775
MZT1	hsa-miR-30d-5p	94.2048	NM_001071775
MZT1	hsa-miR-30a-5p	94.2048	NM_001071775
MZT1	hsa-miR-561-3p	92.0367	NM_001071775
MZT1	hsa-miR-5571-5p	91.689	NM_001071775
MZT1	hsa-miR-374a-5p	91.5253	NM_001071775
MZT1	hsa-miR-9-3p	91.2403	NM_001071775
MZT1	hsa-miR-3680-3p	90.9131	NM_001071775
MZT1	hsa-miR-374b-5p	90.179	NM_001071775
MZT1	hsa-miR-4424	89.1181	NM_001071775
MZT1	hsa-miR-586	88.4779	NM_001071775
MZT1	hsa-miR-505-3p	87.8127	NM_001071775
MZT1	hsa-miR-181a-2-3p	86.7846	NM_001071775
MZT1	hsa-miR-4690-3p	86.0014	NM_001071775
MZT1	hsa-miR-5685	86.0014	NM_001071775
MZT1	hsa-miR-380-3p	85.1462	NM_001071775
MZT1	hsa-miR-4668-3p	84.7299	NM_001071775
MZT1	hsa-miR-548an	84.5805	NM_001071775
MZT1	hsa-miR-520e-5p	84.1444	NM_001071775
MZT1	hsa-miR-576-3p	84.0916	NM_001071775
MZT1	hsa-miR-548au-5p	83.7993	NM_001071775
MZT1	hsa-miR-548o-5p	83.7993	NM_001071775
MZT1	hsa-miR-548ak	83.7993	NM_001071775
MZT1	hsa-miR-548i	83.7993	NM_001071775
MZT1	hsa-miR-548ar-5p	83.7993	NM_001071775
MZT1	hsa-miR-559	83.7993	NM_001071775
MZT1	hsa-miR-548b-5p	83.7993	NM_001071775
MZT1	hsa-miR-548c-5p	83.7993	NM_001071775
MZT1	hsa-miR-548bb-5p	83.7993	NM_001071775
MZT1	hsa-miR-548w	83.7993	NM_001071775
MZT1	hsa-miR-548a-5p	83.7993	NM_001071775
MZT1	hsa-miR-548y	83.7993	NM_001071775
MZT1	hsa-miR-548aq-5p	83.7993	NM_001071775
MZT1	hsa-miR-548h-5p	83.7993	NM_001071775
MZT1	hsa-miR-548ab	83.7993	NM_001071775
MZT1	hsa-miR-548ay-5p	83.7993	NM_001071775
MZT1	hsa-miR-548as-5p	83.7993	NM_001071775
MZT1	hsa-miR-548ad-5p	83.7993	NM_001071775
MZT1	hsa-miR-548am-5p	83.7993	NM_001071775
MZT1	hsa-miR-548ae-5p	83.7993	NM_001071775

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Motifs and transcription factors (TFs) regulating MZT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MZT1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MZT1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MZT1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MZT1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MZT1	transfac_pro__M00652	NRF1 (directAnnotation).
MZT1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MZT1	transfac_pro__M04866	HDAC2 (directAnnotation).
MZT1	jaspar__MA1122.1	TFDP1 (directAnnotation).
MZT1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
MZT1	hdpi__TP73	TP73 (directAnnotation).
MZT1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
MZT1	transfac_pro__M00492	STAT1 (directAnnotation).
MZT1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
MZT1	metacluster_183.4	ETS1 (inferredBy_Orthology).
MZT1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
MZT1	transfac_pro__M04748	GABPA (directAnnotation).
MZT1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
MZT1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MZT1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
MZT1	transfac_pro__M02089	E2F3 (directAnnotation).
MZT1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
MZT1	tfdimers__MD00483	ZBTB14 (directAnnotation).
MZT1	cisbp__M00968	MTF2 (directAnnotation).
MZT1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MZT1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MZT1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."