Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYRF

Summary for MYRF

Gene information	Gene symbol	MYRF
	Ensembl ID	ENSG00000124920
	Entrez ID	745
	Gene name	myelin regulatory factor
	Synonyms	C11orf9\|MRF\|Ndt80\|pqn-47
	Gene type	protein_coding
	UniProtAcc	Q9Y2G1

Top

Dataset with differentially expressed gene: MYRF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.606204	0.00e+00

Top

Expression of MYRF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MYRF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MYRF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYRF	hsa-miR-199b-5p	99.0338	NM_001127392
MYRF	hsa-miR-199a-5p	99.0338	NM_001127392
MYRF	hsa-miR-5195-3p	97.8384	NM_001127392
MYRF	hsa-miR-506-3p	97.7249	NM_001127392
MYRF	hsa-miR-124-3p	97.7249	NM_001127392
MYRF	hsa-miR-6764-5p	97.4786	NM_001127392
MYRF	hsa-miR-1915-3p	97.4325	NM_001127392
MYRF	hsa-miR-145-5p	96.809	NM_001127392
MYRF	hsa-miR-302e	96.3342	NM_001127392
MYRF	hsa-miR-3910	96.0157	NM_001127392
MYRF	hsa-miR-302a-3p	95.2539	NM_001127392
MYRF	hsa-miR-302d-3p	95.2539	NM_001127392
MYRF	hsa-miR-302b-3p	95.2539	NM_001127392
MYRF	hsa-miR-302c-3p	95.2539	NM_001127392
MYRF	hsa-miR-3714	95.1011	NM_001127392
MYRF	hsa-miR-372-3p	94.7891	NM_001127392
MYRF	hsa-miR-520c-3p	94.7891	NM_001127392
MYRF	hsa-miR-520a-3p	94.7891	NM_001127392
MYRF	hsa-miR-373-3p	94.7891	NM_001127392
MYRF	hsa-miR-520b-3p	94.7891	NM_001127392
MYRF	hsa-miR-520d-3p	94.7891	NM_001127392
MYRF	hsa-miR-520e-3p	94.7891	NM_001127392
MYRF	hsa-miR-6721-5p	93.3355	NM_001127392
MYRF	hsa-miR-3925-3p	92.4136	NM_001127392
MYRF	hsa-miR-4441	90.4837	NM_001127392
MYRF	hsa-miR-6760-5p	89.8207	NM_001127392
MYRF	hsa-miR-4729	89.3419	NM_001127392
MYRF	hsa-miR-4290	89.1665	NM_001127392
MYRF	hsa-miR-133b	88.6855	NM_001127392
MYRF	hsa-miR-133a-3p	88.6855	NM_001127392
MYRF	hsa-miR-1825	88.4339	NM_001127392
MYRF	hsa-miR-519a-3p	88.1119	NM_001127392
MYRF	hsa-miR-519b-3p	88.1119	NM_001127392
MYRF	hsa-miR-519c-3p	88.1119	NM_001127392
MYRF	hsa-miR-4699-3p	87.8459	NM_001127392
MYRF	hsa-miR-6859-3p	87.4013	NM_001127392
MYRF	hsa-miR-4673	87.356	NM_001127392
MYRF	hsa-miR-4645-5p	87.356	NM_001127392
MYRF	hsa-miR-9-3p	86.409	NM_001127392
MYRF	hsa-miR-149-3p	86.1399	NM_001127392
MYRF	hsa-miR-6883-5p	86.1399	NM_001127392
MYRF	hsa-miR-4728-5p	85.8527	NM_001127392
MYRF	hsa-miR-6785-5p	85.8527	NM_001127392
MYRF	hsa-miR-4270	83.8821	NM_001127392
MYRF	hsa-miR-5582-5p	83.4078	NM_001127392
MYRF	hsa-miR-6840-3p	83.1925	NM_001127392
MYRF	hsa-miR-4653-3p	82.9656	NM_001127392
MYRF	hsa-miR-508-5p	82.8349	NM_001127392
MYRF	hsa-miR-3192-5p	82.7004	NM_001127392
MYRF	hsa-miR-6878-5p	82.4145	NM_001127392

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating MYRF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."