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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO5C

Summary for MYO5C

Gene information	Gene symbol	MYO5C
	Ensembl ID	ENSG00000128833
	Entrez ID	55930
	Gene name	myosin VC
	Synonyms	MGC74969
	Gene type	protein_coding
	UniProtAcc	Q9NQX4

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Dataset with differentially expressed gene: MYO5C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.38377	2.48e-31

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Expression of MYO5C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYO5C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYO5C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO5C	hsa-miR-373-5p	98.2859	NM_018728
MYO5C	hsa-miR-371b-5p	98.2859	NM_018728
MYO5C	hsa-miR-616-5p	98.2859	NM_018728
MYO5C	hsa-miR-5692b	97.676	NM_018728
MYO5C	hsa-miR-5692c	97.676	NM_018728
MYO5C	hsa-miR-4775	95.9569	NM_018728
MYO5C	hsa-miR-6730-5p	95.585	NM_018728
MYO5C	hsa-miR-4476	95.3249	NM_018728
MYO5C	hsa-miR-6876-5p	95.3249	NM_018728
MYO5C	hsa-miR-4533	93.8167	NM_018728
MYO5C	hsa-miR-7150	92.6099	NM_018728
MYO5C	hsa-miR-4742-3p	92.314	NM_018728
MYO5C	hsa-miR-4736	91.5203	NM_018728
MYO5C	hsa-miR-30d-3p	91.4545	NM_018728
MYO5C	hsa-miR-30a-3p	91.4545	NM_018728
MYO5C	hsa-miR-30e-3p	91.4545	NM_018728
MYO5C	hsa-miR-545-5p	90.8934	NM_018728
MYO5C	hsa-miR-590-3p	90.738	NM_018728
MYO5C	hsa-miR-148a-5p	87.6515	NM_018728
MYO5C	hsa-miR-374a-5p	87.5202	NM_018728
MYO5C	hsa-miR-1182	87.2741	NM_018728
MYO5C	hsa-miR-374b-5p	86.3015	NM_018728
MYO5C	hsa-miR-4282	85.7571	NM_018728
MYO5C	hsa-miR-4705	85.6763	NM_018728
MYO5C	hsa-miR-153-5p	84.5701	NM_018728
MYO5C	hsa-miR-377-5p	83.4635	NM_018728
MYO5C	hsa-miR-6086	82.957	NM_018728
MYO5C	hsa-miR-6875-3p	82.914	NM_018728
MYO5C	hsa-miR-4678	82.8419	NM_018728
MYO5C	hsa-miR-760	81.0344	NM_018728
MYO5C	hsa-miR-6516-3p	80.794	NM_018728

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Motifs and transcription factors (TFs) regulating MYO5C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO5C	metacluster_198.3	ZFP64 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."