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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO1C

Summary for MYO1C

Gene information	Gene symbol	MYO1C
	Ensembl ID	ENSG00000197879
	Entrez ID	4641
	Gene name	myosin IC
	Synonyms	MyoIC\|myr2\|NMI
	Gene type	protein_coding
	UniProtAcc	O00159

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Dataset with differentially expressed gene: MYO1C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.648608	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.284918	2.80e-45
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.371602	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.540957	0.00e+00

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Expression of MYO1C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYO1C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYO1C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO1C	hsa-miR-4492	98.1237	NM_001080779
MYO1C	hsa-miR-3714	96.8799	NM_001080779
MYO1C	hsa-miR-4498	96.1626	NM_001080779
MYO1C	hsa-miR-5001-5p	95.333	NM_001080779
MYO1C	hsa-miR-762	95.2	NM_001080779
MYO1C	hsa-miR-6829-5p	91.9253	NM_001080779
MYO1C	hsa-miR-3191-5p	90.9047	NM_001080779
MYO1C	hsa-miR-122b-5p	89.766	NM_001080779
MYO1C	hsa-miR-4422	89.3264	NM_001080779
MYO1C	hsa-miR-4441	89.1508	NM_001080779
MYO1C	hsa-miR-6721-5p	88.6427	NM_001080779
MYO1C	hsa-miR-5088-3p	88.1817	NM_001080779
MYO1C	hsa-miR-3119	87.614	NM_001080779
MYO1C	hsa-miR-518c-5p	86.9566	NM_001080779
MYO1C	hsa-miR-298	86.6356	NM_001080779
MYO1C	hsa-miR-6785-5p	86.6165	NM_001080779
MYO1C	hsa-miR-4728-5p	86.6165	NM_001080779
MYO1C	hsa-miR-1910-3p	86.5429	NM_001080779
MYO1C	hsa-miR-6511a-5p	86.5429	NM_001080779
MYO1C	hsa-miR-9-5p	86.371	NM_001080779
MYO1C	hsa-miR-149-3p	86.2396	NM_001080779
MYO1C	hsa-miR-4642	85.4582	NM_001080779
MYO1C	hsa-miR-124-3p	83.6051	NM_001080779
MYO1C	hsa-miR-506-3p	83.6051	NM_001080779
MYO1C	hsa-miR-330-3p	82.6662	NM_001080779
MYO1C	hsa-miR-6793-5p	82.4335	NM_001080779
MYO1C	hsa-miR-3910	82.0166	NM_001080779
MYO1C	hsa-miR-6883-5p	82.0001	NM_001080779
MYO1C	hsa-miR-4470	81.7128	NM_001080779
MYO1C	hsa-miR-372-5p	81.2346	NM_001080779
MYO1C	hsa-miR-4270	80.1112	NM_001080779

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Motifs and transcription factors (TFs) regulating MYO1C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO1C	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MYO1C	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MYO1C	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MYO1C	cisbp__M08198	ELF1 (directAnnotation).
MYO1C	transfac_pro__M06109	ZNF254 (directAnnotation).
MYO1C	transfac_pro__M06032	ZNF727 (directAnnotation).
MYO1C	metacluster_172.6	CHD2; E2F1 (directAnnotation).
MYO1C	transfac_pro__M05835	ZNF628 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."