Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO1B

Summary for MYO1B

Gene information	Gene symbol	MYO1B
	Ensembl ID	ENSG00000128641
	Entrez ID	4430
	Gene name	myosin IB
	Synonyms	myr1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: MYO1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.257925	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.269323	7.52e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.431643	4.88e-27
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.734078	0.00e+00

Top

Expression of MYO1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MYO1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MYO1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO1B	hsa-miR-92a-3p	99.2668	NM_001130158
MYO1B	hsa-miR-92b-3p	99.2668	NM_001130158
MYO1B	hsa-miR-32-5p	99.2668	NM_001130158
MYO1B	hsa-miR-25-3p	99.1946	NM_001130158
MYO1B	hsa-miR-363-3p	99.1946	NM_001130158
MYO1B	hsa-miR-367-3p	99.1946	NM_001130158
MYO1B	hsa-miR-5582-3p	97.6878	NM_001130158
MYO1B	hsa-miR-6882-5p	97.3752	NM_001130158
MYO1B	hsa-miR-29b-1-5p	95.8443	NM_012223
MYO1B	hsa-miR-33a-3p	95.6435	NM_012223
MYO1B	hsa-miR-9851-3p	94.188	NM_012223
MYO1B	hsa-miR-593-5p	93.5851	NM_012223
MYO1B	hsa-miR-4325	93.0208	NM_001130158
MYO1B	hsa-miR-7703	93.0208	NM_001130158
MYO1B	hsa-miR-6749-3p	92.7189	NM_012223
MYO1B	hsa-miR-6761-5p	92.2705	NM_012223
MYO1B	hsa-miR-340-5p	92.0665	NM_001130158
MYO1B	hsa-miR-548ar-3p	91.4221	NM_001130158
MYO1B	hsa-miR-580-5p	90.8841	NM_001130158
MYO1B	hsa-miR-935	89.8111	NM_001130158
MYO1B	hsa-miR-656-3p	89.6258	NM_012223
MYO1B	hsa-miR-4795-3p	89.2797	NM_001130158
MYO1B	hsa-miR-516b-5p	88.9499	NM_012223
MYO1B	hsa-miR-548az-3p	88.5422	NM_001130158
MYO1B	hsa-miR-548bc	88.5422	NM_001130158
MYO1B	hsa-miR-548f-3p	88.5422	NM_001130158
MYO1B	hsa-miR-548a-3p	88.5422	NM_001130158
MYO1B	hsa-miR-548e-3p	88.5422	NM_001130158
MYO1B	hsa-miR-1266-3p	87.6213	NM_012223
MYO1B	hsa-miR-3622b-5p	86.435	NM_001130158
MYO1B	hsa-miR-6505-3p	86.0574	NM_012223
MYO1B	hsa-miR-488-3p	85.1685	NM_012223
MYO1B	hsa-miR-4502	84.1694	NM_012223
MYO1B	hsa-miR-6799-3p	83.136	NM_001130158
MYO1B	hsa-miR-3173-5p	83.136	NM_001130158
MYO1B	hsa-miR-9903	82.372	NM_012223
MYO1B	hsa-miR-202-5p	82.1628	NM_001130158
MYO1B	hsa-miR-224-5p	81.9544	NM_012223
MYO1B	hsa-miR-570-3p	81.1824	NM_012223
MYO1B	hsa-miR-888-5p	80.8956	NM_012223
MYO1B	hsa-miR-6843-3p	80.675	NM_012223
MYO1B	hsa-miR-6848-3p	80.675	NM_012223

Page: 1

Top

Motifs and transcription factors (TFs) regulating MYO1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO1B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MYO1B	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MYO1B	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MYO1B	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MYO1B	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MYO1B	transfac_pro__M00652	NRF1 (directAnnotation).
MYO1B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MYO1B	transfac_pro__M04866	HDAC2 (directAnnotation).
MYO1B	jaspar__MA1122.1	TFDP1 (directAnnotation).
MYO1B	metacluster_135.11	NR2C2 (directAnnotation).
MYO1B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MYO1B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MYO1B	metacluster_7.13	ZFX (directAnnotation).
MYO1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MYO1B	cisbp__M00968	MTF2 (directAnnotation).
MYO1B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MYO1B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MYO1B	cisbp__M00341	PAX6 (directAnnotation).
MYO1B	metacluster_198.3	ZFP64 (directAnnotation).
MYO1B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MYO1B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MYO1B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MYO1B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MYO1B	cisbp__M00788	ZFY (inferredBy_Orthology).
MYO1B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MYO1B	metacluster_175.1	ZNF283 (directAnnotation).
MYO1B	hdpi__ZNF304	ZNF304 (directAnnotation).
MYO1B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MYO1B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MYO1B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MYO1B	transfac_pro__M01199	TRIM28 (directAnnotation).
MYO1B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MYO1B	metacluster_151.2	ZNF23 (directAnnotation).
MYO1B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYO1B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MYO1B	transfac_pro__M03806	ZBTB7C (directAnnotation).
MYO1B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYO1B	transfac_pro__M04826	EP300 (directAnnotation).
MYO1B	swissregulon__hs__ELF2	ELF2 (directAnnotation).
MYO1B	hdpi__ELF2	ELF2 (directAnnotation).
MYO1B	swissregulon__hs__ELK1	ELK1 (directAnnotation).
MYO1B	metacluster_183.4	ETS1 (inferredBy_Orthology).
MYO1B	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
MYO1B	transfac_pro__M04862	NRF1 (directAnnotation).
MYO1B	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MYO1B	metacluster_81.7	CREB1 (directAnnotation).
MYO1B	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."