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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO18A

Summary for MYO18A

Gene information	Gene symbol	MYO18A
	Ensembl ID	ENSG00000196535
	Entrez ID	399687
	Gene name	myosin XVIIIA
	Synonyms	KIAA0216\|MysPDZ\|TIAF1
	Gene type	protein_coding
	UniProtAcc	Q92614

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Dataset with differentially expressed gene: MYO18A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.30305	6.31e-13

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Expression of MYO18A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYO18A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYO18A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO18A	hsa-miR-1266-5p	96.2136	NM_078471
MYO18A	hsa-miR-4518	96.2136	NM_078471
MYO18A	hsa-miR-4447	94.7665	NM_203318
MYO18A	hsa-miR-503-3p	92.8868	NM_203318
MYO18A	hsa-miR-6783-3p	91.9205	NM_078471
MYO18A	hsa-miR-6715b-5p	91.1525	NM_078471
MYO18A	hsa-miR-4319	89.8518	NM_078471
MYO18A	hsa-miR-1343-3p	89.4226	NM_078471
MYO18A	hsa-miR-210-5p	89.1156	NM_203318
MYO18A	hsa-miR-6856-3p	89.02	NM_078471
MYO18A	hsa-miR-4269	88.4123	NM_078471
MYO18A	hsa-miR-4534	88.2634	NM_203318
MYO18A	hsa-miR-4524a-3p	87.2514	NM_078471
MYO18A	hsa-miR-125a-5p	85.9025	NM_078471
MYO18A	hsa-miR-125b-5p	85.9025	NM_078471
MYO18A	hsa-miR-4472	85.3061	NM_203318
MYO18A	hsa-miR-593-5p	84.7866	NM_078471
MYO18A	hsa-miR-9851-3p	84.7866	NM_078471
MYO18A	hsa-miR-4441	84.0457	NM_078471
MYO18A	hsa-miR-92a-2-5p	82.3884	NM_203318
MYO18A	hsa-miR-8082	82.2425	NM_203318
MYO18A	hsa-miR-4660	80.3455	NM_203318

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Motifs and transcription factors (TFs) regulating MYO18A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO18A	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MYO18A	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."