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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO10

Summary for MYO10

Gene information	Gene symbol	MYO10
	Ensembl ID	ENSG00000145555
	Entrez ID	4651
	Gene name	myosin X
	Synonyms	KIAA0799\|MyoX
	Gene type	protein_coding
	UniProtAcc	Q9HD67

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Dataset with differentially expressed gene: MYO10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.30287	7.27e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.265668	1.59e-07
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.312543	1.61e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.445983	0.00e+00

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Expression of MYO10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYO10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MYO10	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MYO10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO10	hsa-miR-124-3p	95.4551	NM_012334
MYO10	hsa-miR-506-3p	95.4551	NM_012334
MYO10	hsa-miR-6780a-5p	95.2691	NM_012334
MYO10	hsa-miR-3689c	94.7483	NM_012334
MYO10	hsa-miR-3689b-3p	94.7483	NM_012334
MYO10	hsa-miR-3689a-3p	94.7483	NM_012334
MYO10	hsa-miR-6779-5p	94.7483	NM_012334
MYO10	hsa-miR-1273h-5p	94.7483	NM_012334
MYO10	hsa-miR-30b-3p	94.7483	NM_012334
MYO10	hsa-miR-9-3p	94.5005	NM_012334
MYO10	hsa-miR-6799-5p	93.7075	NM_012334
MYO10	hsa-miR-3194-3p	92.5625	NM_012334
MYO10	hsa-miR-6852-3p	91.0582	NM_012334
MYO10	hsa-miR-3120-3p	90.5184	NM_012334
MYO10	hsa-miR-95-5p	89.5475	NM_012334
MYO10	hsa-miR-4728-5p	89.4423	NM_012334
MYO10	hsa-miR-3132	88.0587	NM_012334
MYO10	hsa-miR-6785-5p	87.8118	NM_012334
MYO10	hsa-miR-6887-3p	87.0654	NM_012334
MYO10	hsa-miR-197-5p	87.0313	NM_012334
MYO10	hsa-miR-3909	86.8396	NM_012334
MYO10	hsa-miR-4671-3p	86.3879	NM_012334
MYO10	hsa-miR-3910	86.1839	NM_012334
MYO10	hsa-miR-3163	85.2463	NM_012334
MYO10	hsa-miR-340-5p	84.8388	NM_012334
MYO10	hsa-miR-3714	84.067	NM_012334
MYO10	hsa-miR-802	82.9137	NM_012334
MYO10	hsa-miR-155-5p	82.8442	NM_012334
MYO10	hsa-miR-5701	81.7707	NM_012334
MYO10	hsa-miR-607	80.736	NM_012334
MYO10	hsa-miR-7106-5p	80.4179	NM_012334
MYO10	hsa-miR-149-3p	80.2643	NM_012334
MYO10	hsa-miR-6883-5p	80.2643	NM_012334
MYO10	hsa-miR-218-1-3p	80.033	NM_012334

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Motifs and transcription factors (TFs) regulating MYO10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO10	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
MYO10	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
MYO10	metacluster_52.11	ZNF184 (directAnnotation).
MYO10	metacluster_98.1	ZNF524 (directAnnotation).
MYO10	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
MYO10	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
MYO10	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MYO10	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
MYO10	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MYO10	transfac_pro__M04617	ZBTB7A (directAnnotation).
MYO10	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MYO10	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MYO10	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MYO10	transfac_pro__M07387	ZBTB7A (directAnnotation).
MYO10	transfac_pro__M07436	WT1 (directAnnotation).
MYO10	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MYO10	transfac_pro__M00716	ZBTB14 (directAnnotation).
MYO10	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MYO10	hdpi__HIP2	UBE2K (directAnnotation).
MYO10	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MYO10	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MYO10	transfac_pro__M04893	TAF1 (directAnnotation).
MYO10	transfac_pro__M03876	ZBTB33 (directAnnotation).
MYO10	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MYO10	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MYO10	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
MYO10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MYO10	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MYO10	transfac_pro__M04826	EP300 (directAnnotation).
MYO10	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MYO10	hdpi__ETV4	ETV4 (directAnnotation).
MYO10	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MYO10	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MYO10	jaspar__MA0748.2	YY2 (directAnnotation).
MYO10	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
MYO10	transfac_pro__M00492	STAT1 (directAnnotation).
MYO10	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
MYO10	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
MYO10	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
MYO10	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."