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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MYLK3

Summary for MYLK3

Gene information	Gene symbol	MYLK3
	Ensembl ID	ENSG00000140795
	Entrez ID	91807
	Gene name	myosin light chain kinase 3
	Synonyms	caMLCK\|MLCK
	Gene type	protein_coding
	UniProtAcc	Q32MK0

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Dataset with differentially expressed gene: MYLK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.721117	2.46e-03

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Expression of MYLK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYLK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYLK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYLK3	hsa-miR-371b-5p	97.5176	NM_182493
MYLK3	hsa-miR-616-5p	97.5176	NM_182493
MYLK3	hsa-miR-373-5p	97.5176	NM_182493
MYLK3	hsa-miR-6867-5p	96.992	NM_182493
MYLK3	hsa-miR-1910-3p	95.1683	NM_182493
MYLK3	hsa-miR-6511a-5p	94.8223	NM_182493
MYLK3	hsa-miR-6515-3p	92.5324	NM_182493
MYLK3	hsa-miR-3613-3p	92.4212	NM_182493
MYLK3	hsa-miR-12117	92.0407	NM_182493
MYLK3	hsa-miR-590-3p	89.9573	NM_182493
MYLK3	hsa-miR-4668-3p	89.5231	NM_182493
MYLK3	hsa-miR-130b-5p	85.8863	NM_182493
MYLK3	hsa-miR-1301-5p	84.7029	NM_182493
MYLK3	hsa-miR-6502-5p	84.7029	NM_182493
MYLK3	hsa-miR-583	84.4587	NM_182493
MYLK3	hsa-miR-8068	83.6083	NM_182493
MYLK3	hsa-miR-95-5p	83.0515	NM_182493
MYLK3	hsa-miR-607	82.8433	NM_182493
MYLK3	hsa-miR-6844	82.8064	NM_182493
MYLK3	hsa-miR-3658	82.5495	NM_182493
MYLK3	hsa-miR-5700	82.4382	NM_182493
MYLK3	hsa-miR-4666a-5p	81.2641	NM_182493
MYLK3	hsa-miR-1245a	81.2503	NM_182493

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Motifs and transcription factors (TFs) regulating MYLK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MYLK3	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."