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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYH10

Summary for MYH10

Gene information	Gene symbol	MYH10
	Ensembl ID	ENSG00000133026
	Entrez ID	4628
	Gene name	myosin heavy chain 10
	Synonyms	NMMHCB
	Gene type	protein_coding
	UniProtAcc	P35580

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Dataset with differentially expressed gene: MYH10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.294769	6.70e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.39539	0.00e+00

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Expression of MYH10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYH10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYH10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYH10	hsa-miR-141-3p	98.8754	NM_001256012
MYH10	hsa-miR-200a-3p	98.8754	NM_001256012
MYH10	hsa-miR-3688-3p	97.884	NM_001256012
MYH10	hsa-miR-550a-3p	97.7369	NM_001256012
MYH10	hsa-miR-200c-5p	97.237	NM_001256012
MYH10	hsa-miR-1252-5p	96.9104	NM_001256012
MYH10	hsa-miR-6843-3p	93.9018	NM_001256012
MYH10	hsa-miR-6848-3p	93.9018	NM_001256012
MYH10	hsa-miR-6508-5p	93.7852	NM_001256012
MYH10	hsa-miR-8076	93.7668	NM_001256012
MYH10	hsa-miR-8067	93.738	NM_001256012
MYH10	hsa-miR-5701	93.3672	NM_001256012
MYH10	hsa-miR-5011-5p	93.277	NM_001256012
MYH10	hsa-miR-3148	93.0382	NM_001256012
MYH10	hsa-miR-6760-3p	91.3415	NM_001256012
MYH10	hsa-miR-770-5p	89.8816	NM_001256012
MYH10	hsa-miR-4712-5p	89.8816	NM_001256012
MYH10	hsa-miR-181b-3p	89.6774	NM_001256012
MYH10	hsa-miR-181b-2-3p	89.6774	NM_001256012
MYH10	hsa-miR-381-3p	89.5818	NM_001256012
MYH10	hsa-miR-300	89.5818	NM_001256012
MYH10	hsa-miR-2467-3p	89.0857	NM_001256012
MYH10	hsa-miR-124-3p	89.0134	NM_001256012
MYH10	hsa-miR-506-3p	89.0134	NM_001256012
MYH10	hsa-miR-4420	88.9252	NM_001256012
MYH10	hsa-miR-10400-3p	88.7864	NM_001256012
MYH10	hsa-miR-4674	88.7864	NM_001256012
MYH10	hsa-miR-1178-3p	87.8634	NM_001256012
MYH10	hsa-miR-3678-3p	87.6421	NM_001256012
MYH10	hsa-miR-9-3p	86.8941	NM_001256012
MYH10	hsa-miR-505-3p	85.9702	NM_001256012
MYH10	hsa-miR-6165	85.4319	NM_001256012
MYH10	hsa-miR-6124	85.3079	NM_001256012
MYH10	hsa-miR-4437	84.693	NM_001256012
MYH10	hsa-miR-4289	83.9363	NM_001256012
MYH10	hsa-miR-142-3p	82.781	NM_001256012
MYH10	hsa-miR-4272	82.7168	NM_001256012
MYH10	hsa-miR-9985	82.4999	NM_001256012
MYH10	hsa-miR-27b-3p	82.4999	NM_001256012
MYH10	hsa-miR-27a-3p	82.4999	NM_001256012
MYH10	hsa-miR-26a-5p	81.756	NM_001256012
MYH10	hsa-miR-1297	81.756	NM_001256012
MYH10	hsa-miR-26b-5p	81.756	NM_001256012
MYH10	hsa-miR-1278	81.221	NM_001256012
MYH10	hsa-miR-3617-5p	80.9288	NM_001256012
MYH10	hsa-miR-641	80.9288	NM_001256012
MYH10	hsa-miR-3163	80.9213	NM_001256012

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Motifs and transcription factors (TFs) regulating MYH10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYH10	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MYH10	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MYH10	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MYH10	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MYH10	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MYH10	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."