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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYCL

Summary for MYCL

Gene information	Gene symbol	MYCL
	Ensembl ID	ENSG00000116990
	Entrez ID	4610
	Gene name	MYCL proto-oncogene, bHLH transcription factor
	Synonyms	bHLHe38\|LMYC\|MYCL1
	Gene type	protein_coding
	UniProtAcc	P12524

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Dataset with differentially expressed gene: MYCL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.328697	0.00e+00

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Expression of MYCL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYCL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYCL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYCL	hsa-miR-1294	97.5847	NM_001033081
MYCL	hsa-miR-9986	97.5847	NM_001033081
MYCL	hsa-miR-4666a-3p	95.4292	NM_001033081
MYCL	hsa-miR-6733-5p	94.0528	NM_001033082
MYCL	hsa-miR-6739-5p	94.0528	NM_001033082
MYCL	hsa-miR-19b-3p	93.8056	NM_001033081
MYCL	hsa-miR-19a-3p	93.8056	NM_001033081
MYCL	hsa-miR-338-5p	93.1864	NM_001033081
MYCL	hsa-miR-6720-5p	93.1368	NM_005376
MYCL	hsa-miR-6512-3p	93.1368	NM_005376
MYCL	hsa-miR-1299	92.8825	NM_001033082
MYCL	hsa-miR-3153	92.5632	NM_001033082
MYCL	hsa-miR-6833-3p	90.672	NM_005376
MYCL	hsa-miR-539-5p	88.7032	NM_001033081
MYCL	hsa-miR-4314	88.4948	NM_001033082
MYCL	hsa-miR-4768-5p	88.19	NM_005376
MYCL	hsa-miR-6731-5p	87.2825	NM_001033082
MYCL	hsa-miR-8085	87.2825	NM_001033082
MYCL	hsa-miR-454-5p	87.2664	NM_005376
MYCL	hsa-miR-939-3p	87.2598	NM_001033082
MYCL	hsa-miR-122b-3p	86.8159	NM_001033082
MYCL	hsa-miR-21-3p	86.8159	NM_001033082
MYCL	hsa-miR-10526-3p	83.924	NM_001033082
MYCL	hsa-miR-6506-5p	83.0762	NM_001033081
MYCL	hsa-miR-619-5p	83.0762	NM_001033081
MYCL	hsa-miR-646	82.9087	NM_001033081
MYCL	hsa-miR-1207-3p	82.3483	NM_001033082
MYCL	hsa-miR-6129	82.0553	NM_001033082
MYCL	hsa-miR-6133	82.0553	NM_001033082
MYCL	hsa-miR-3910	81.386	NM_001033082
MYCL	hsa-miR-6780b-3p	80.5237	NM_001033082

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Motifs and transcription factors (TFs) regulating MYCL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."