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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: MYC

Summary for MYC

Gene information	Gene symbol	MYC
	Ensembl ID	ENSG00000136997
	Entrez ID	4609
	Gene name	MYC proto-oncogene, bHLH transcription factor
	Synonyms	bHLHe39\|c-Myc\|MYCC
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MYC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.284554	1.83e-17
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Progenitors	-0.460431	3.12e-02
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.397638	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.274796	2.06e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.60891	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.702799	4.02e-08
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.39471	6.28e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.683602	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.576086	1.52e-40
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.926969	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.865103	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.695644	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.702242	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	B cells	-0.259007	5.43e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.436606	1.21e-04

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Expression of MYC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MYC	Regulation by the Disease Microenvironment
MYC	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MYC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYC	hsa-miR-548aj-3p	98.7084	NM_002467
MYC	hsa-miR-548x-3p	98.7084	NM_002467
MYC	hsa-miR-548ae-3p	98.5838	NM_002467
MYC	hsa-miR-548z	98.5838	NM_002467
MYC	hsa-miR-548aq-3p	98.5838	NM_002467
MYC	hsa-miR-548am-3p	98.5838	NM_002467
MYC	hsa-miR-548ac	98.5838	NM_002467
MYC	hsa-miR-548h-3p	98.5838	NM_002467
MYC	hsa-miR-548d-3p	98.5838	NM_002467
MYC	hsa-miR-548bb-3p	98.5838	NM_002467
MYC	hsa-miR-548j-3p	98.5838	NM_002467
MYC	hsa-miR-548ah-3p	98.5838	NM_002467
MYC	hsa-miR-1304-5p	95.7384	NM_002467
MYC	hsa-miR-4699-3p	93.2632	NM_002467
MYC	hsa-miR-1827	92.1274	NM_002467
MYC	hsa-miR-5197-5p	92.0821	NM_002467
MYC	hsa-miR-4652-3p	91.7419	NM_002467
MYC	hsa-miR-34b-5p	91.3811	NM_002467
MYC	hsa-miR-2682-5p	90.0555	NM_002467
MYC	hsa-miR-449c-5p	90.0555	NM_002467
MYC	hsa-miR-548au-3p	87.9759	NM_002467
MYC	hsa-miR-1294	87.6137	NM_002467
MYC	hsa-miR-9986	87.6137	NM_002467
MYC	hsa-miR-548at-5p	84.9401	NM_002467
MYC	hsa-miR-4282	82.7277	NM_002467
MYC	hsa-miR-5692a	80.3928	NM_002467

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Motifs and transcription factors (TFs) regulating MYC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYC	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MYC	transfac_pro__M04748	GABPA (directAnnotation).
MYC	transfac_public__M00024	E2F1 (directAnnotation).
MYC	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
MYC	jaspar__MA0776.1	MYBL1 (directAnnotation).
MYC	transfac_pro__M01182	HINFP (directAnnotation).
MYC	hdpi__FLI1	FLI1 (directAnnotation).
MYC	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
MYC	transfac_pro__M05349	SNAI3 (directAnnotation).
MYC	transfac_pro__M05930	ZNF286A (directAnnotation).
MYC	transfac_pro__M06196	ZNF81 (directAnnotation).
MYC	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
MYC	kznf__ZNF443_Imbeault2017_RP_RCADE	ZNF443 (directAnnotation).
MYC	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
MYC	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
MYC	metacluster_131.3	ZNF436 (inferredBy_Orthology).
MYC	metacluster_196.7	POLR3A (directAnnotation).
MYC	transfac_pro__M06259	ZNF91 (directAnnotation).
MYC	metacluster_135.11	NR2C2 (directAnnotation).
MYC	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MYC	taipale__MYBL2_DBD_AACCGTTAACGGNN	MYBL2 (directAnnotation).
MYC	transfac_pro__M05888	ZNF467 (inferredBy_Orthology).
MYC	tfdimers__MD00136	E2F6; GATA3 (directAnnotation).
MYC	metacluster_168.4	ZNF652 (directAnnotation).
MYC	metacluster_141.4	GLIS2 (directAnnotation).
MYC	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
MYC	transfac_pro__M05721	ZNF235 (directAnnotation).
MYC	metacluster_140.3	NKX2-3; NKX2-5; NKX2-8 (directAnnotation).
MYC	tfdimers__MD00516	SOX10 (directAnnotation).
MYC	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MYC	transfac_pro__M05851	ZNF768 (inferredBy_Orthology).
MYC	transfac_pro__M06019	ZNF98 (directAnnotation).
MYC	transfac_pro__M06959	ZNF425 (directAnnotation).
MYC	taipale_tf_pairs__ELK1_PAX9_RSCGGAACYACGCWYSANTG_CAP	ELK1; PAX9 (directAnnotation).
MYC	transfac_pro__M04855	IRF4 (directAnnotation).
MYC	taipale_tf_pairs__PITX1_EOMES_RGGTGTKANNNNGGATTA_CAP_repr	EOMES; PITX1 (directAnnotation).
MYC	hdpi__PRKRIR	THAP12 (directAnnotation).
MYC	transfac_pro__M06493	ZNF668 (inferredBy_Orthology).
MYC	metacluster_140.8	ZNF564 (directAnnotation).
MYC	metacluster_178.16	ZNF660; ZNF660 (directAnnotation).
MYC	tfdimers__MD00490	CDX2; SOX2 (directAnnotation).
MYC	transfac_pro__M06953	VAX1 (inferredBy_Orthology).
MYC	transfac_pro__M05354	ZNF800 (inferredBy_Orthology).
MYC	tfdimers__MD00440	FOXI1; IRF1 (directAnnotation).
MYC	tfdimers__MD00256	HOXA13 (directAnnotation).
MYC	transfac_pro__M06504	ZFP62 (directAnnotation).
MYC	transfac_pro__M06806	PEG3 (directAnnotation).
MYC	transfac_public__M00041	ATF2; JUN (directAnnotation).
MYC	jaspar__MA1657.1	ZNF652 (directAnnotation).
MYC	metacluster_168.14	ZNF33A; ZNF33B; ZNF394; ZNF768 (directAnnotation). ZNF768 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MYC	metacluster_156.2	up	Malignant cells	GSE161801_IMiD	post
MYC	transfac_public__M00123	down	B cells	GSE161801_IMiD	pre
MYC	homer__NCCACGTG_c-Myc	down	Progenitors	GSE197268_Axi-cel	post
MYC	homer__NCCACGTG_c-Myc	up	Malignant cells	GSE199333	post
MYC	transfac_pro__M00322	down	Malignant cells	GSE207422_Tor	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MYC	"Acetylsalicylic acid"	DB00945	small molecule
MYC	"Dimethyl sulfoxide"	DB01093	small molecule
MYC	"Doconexent"	DB03756	small molecule
MYC	"Nadroparin"	DB08813	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."