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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MXRA7

Summary for MXRA7

Gene information	Gene symbol	MXRA7
	Ensembl ID	ENSG00000182534
	Entrez ID	439921
	Gene name	matrix remodeling associated 7
	Synonyms	FLJ46603\|PS1TP1\|TMAP1
	Gene type	protein_coding
	UniProtAcc	P84157

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Dataset with differentially expressed gene: MXRA7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.923868	6.25e-15
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.437347	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.281457	7.23e-14
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.740642	0.00e+00

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Expression of MXRA7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MXRA7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MXRA7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MXRA7	hsa-miR-592	91.3553	NM_198530
MXRA7	hsa-miR-3616-3p	88.9226	NM_198530
MXRA7	hsa-miR-3168	87.9269	NM_001008528
MXRA7	hsa-miR-4263	87.4103	NM_198530
MXRA7	hsa-miR-4728-5p	83.3096	NM_001008528
MXRA7	hsa-miR-3074-5p	82.2502	NM_001008528
MXRA7	hsa-miR-5688	82.1025	NM_001008528
MXRA7	hsa-miR-495-3p	81.7712	NM_001008528
MXRA7	hsa-miR-6785-5p	81.3673	NM_001008528
MXRA7	hsa-miR-4758-5p	80.2808	NM_198530
MXRA7	hsa-miR-1238-5p	80.2808	NM_198530
MXRA7	hsa-miR-3663-5p	80.0996	NM_001008528
MXRA7	hsa-miR-4641	80.0705	NM_001008528

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Motifs and transcription factors (TFs) regulating MXRA7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MXRA7	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MXRA7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MXRA7	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MXRA7	transfac_pro__M07387	ZBTB7A (directAnnotation).
MXRA7	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MXRA7	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
MXRA7	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MXRA7	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MXRA7	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MXRA7	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MXRA7	jaspar__MA0079.5	SP1 (directAnnotation).
MXRA7	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
MXRA7	transfac_pro__M01253	CNOT3 (directAnnotation).
MXRA7	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
MXRA7	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
MXRA7	metacluster_74.6	HNF1A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."