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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MTURN

Summary for MTURN

Gene information	Gene symbol	MTURN
	Ensembl ID	ENSG00000180354
	Entrez ID	222166
	Gene name	maturin, neural progenitor differentiation regulator homolog
	Synonyms	C7orf41\|Ells1\|FLJ25903
	Gene type	protein_coding
	UniProtAcc	Q8N3F0

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Dataset with differentially expressed gene: MTURN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Mono/Macro	-0.736966	4.38e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.426913	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.471796	4.25e-39
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.526357	0.00e+00

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Expression of MTURN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTURN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTURN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTURN	hsa-miR-12136	97.5629	NM_152793
MTURN	hsa-miR-6885-3p	96.2639	NM_152793
MTURN	hsa-miR-4328	93.9127	NM_152793
MTURN	hsa-miR-9985	92.9952	NM_152793
MTURN	hsa-miR-27a-3p	92.9952	NM_152793
MTURN	hsa-miR-27b-3p	92.9952	NM_152793
MTURN	hsa-miR-488-3p	92.732	NM_152793
MTURN	hsa-miR-549a-5p	90.7556	NM_152793
MTURN	hsa-miR-3116	89.5801	NM_152793
MTURN	hsa-miR-4262	89.538	NM_152793
MTURN	hsa-miR-4639-3p	86.4794	NM_152793
MTURN	hsa-miR-4691-3p	84.6563	NM_152793
MTURN	hsa-miR-7110-3p	84.1902	NM_152793
MTURN	hsa-miR-6815-3p	83.0569	NM_152793
MTURN	hsa-miR-218-5p	82.776	NM_152793
MTURN	hsa-miR-181b-5p	81.3232	NM_152793
MTURN	hsa-miR-181a-5p	81.3232	NM_152793
MTURN	hsa-miR-181c-5p	81.3232	NM_152793
MTURN	hsa-miR-181d-5p	81.3232	NM_152793

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Motifs and transcription factors (TFs) regulating MTURN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTURN	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MTURN	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MTURN	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MTURN	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MTURN	transfac_pro__M04950	EGR1 (directAnnotation).
MTURN	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MTURN	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MTURN	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MTURN	jaspar__MA1122.1	TFDP1 (directAnnotation).
MTURN	jaspar__MA0079.5	SP1 (directAnnotation).
MTURN	transfac_pro__M01253	CNOT3 (directAnnotation).
MTURN	transfac_pro__M04817	ZBTB33 (directAnnotation).
MTURN	transfac_pro__M05712	ZNF134 (directAnnotation).
MTURN	cisbp__M07938	E2F1 (directAnnotation).
MTURN	cisbp__M02323	TERF2 (inferredBy_Orthology).
MTURN	transfac_pro__M05950	ZNF700 (directAnnotation).
MTURN	transfac_pro__M06568	ZNF501 (directAnnotation).
MTURN	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
MTURN	jaspar__MA1951.1	FOS (directAnnotation).
MTURN	metacluster_117.5	ZFP41 (directAnnotation). GATA5; ZFP41 (inferredBy_Orthology).
MTURN	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
MTURN	transfac_pro__M05542	SNAPC4 (directAnnotation).
MTURN	transfac_pro__M05469	SALL1 (directAnnotation).
MTURN	transfac_pro__M05864	ZNF615 (directAnnotation).
MTURN	transfac_pro__M05991	ZFP64 (directAnnotation).
MTURN	tfdimers__MD00460	MYOG (directAnnotation).
MTURN	transfac_pro__M06170	ZNF90 (directAnnotation).
MTURN	tfdimers__MD00190	ARID3A; WT1 (directAnnotation).
MTURN	metacluster_72.3	ZNF329 (directAnnotation). ZNF329; ZNF667 (inferredBy_Orthology).
MTURN	kznf__ZNF777_Isakova2017_SMiLE-seq	ZNF777 (directAnnotation).
MTURN	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
MTURN	transfac_public__M00095	CUX1 (directAnnotation).
MTURN	transfac_pro__M06779	ZNF490 (directAnnotation).
MTURN	taipale_tf_pairs__GCM1_FOXO1_GTMAATAAGGGYRN_CAP	FOXO1; GCM1 (directAnnotation).
MTURN	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
MTURN	transfac_pro__M05529	ZBTB5 (inferredBy_Orthology).
MTURN	kznf__MZF1_Najafabadi2015_ChIP-seq	MZF1 (directAnnotation).
MTURN	transfac_pro__M06233	ZNF91 (directAnnotation).
MTURN	taipale_tf_pairs__TEAD4_EOMES_RGGTGTNNNNNNNNGAATGYN_CAP_repr	EOMES; TEAD4 (directAnnotation).
MTURN	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
MTURN	taipale_tf_pairs__TEAD4_HOXB13_GGWATGNNNRTAAA_CAP	HOXB13; TEAD4 (directAnnotation).
MTURN	tfdimers__MD00502	PBX1; SOX9 (directAnnotation).
MTURN	transfac_pro__M06084	ZNF208 (directAnnotation).
MTURN	taipale_tf_pairs__TEAD4_FIGLA_GGAATKNNCASSTG_CAP_repr	FIGLA; TEAD4 (directAnnotation).
MTURN	transfac_public__M00413	ZEB1 (directAnnotation).
MTURN	metacluster_38.2	STAT3 (inferredBy_Orthology).
MTURN	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
MTURN	transfac_pro__M06643	ZNF583 (directAnnotation).
MTURN	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
MTURN	transfac_pro__M05984	ZNF586 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."