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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MTRR

Summary for MTRR

Gene information	Gene symbol	MTRR
	Ensembl ID	ENSG00000124275
	Entrez ID	4552
	Gene name	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
	Synonyms	cblE
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MTRR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.268745	0.00e+00

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Expression of MTRR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTRR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTRR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTRR	hsa-miR-338-5p	95.5183	NM_024010
MTRR	hsa-miR-374a-3p	93.7617	NM_024010
MTRR	hsa-miR-4637	92.2769	NM_024010
MTRR	hsa-miR-19a-3p	92.1544	NM_024010
MTRR	hsa-miR-19b-3p	92.1544	NM_024010
MTRR	hsa-miR-2115-3p	90.4783	NM_024010
MTRR	hsa-miR-4433b-3p	90.092	NM_024010
MTRR	hsa-miR-409-3p	89.1519	NM_024010
MTRR	hsa-miR-421	88.451	NM_024010
MTRR	hsa-miR-361-5p	88.2926	NM_024010
MTRR	hsa-miR-373-5p	87.0651	NM_024010
MTRR	hsa-miR-616-5p	87.0651	NM_024010
MTRR	hsa-miR-371b-5p	87.0651	NM_024010
MTRR	hsa-miR-3164	86.8897	NM_024010
MTRR	hsa-miR-6820-3p	86.8897	NM_024010
MTRR	hsa-miR-16-1-3p	85.1607	NM_024010
MTRR	hsa-miR-4668-5p	83.133	NM_024010
MTRR	hsa-miR-4666a-3p	82.1955	NM_024010
MTRR	hsa-miR-3115	81.9932	NM_024010
MTRR	hsa-miR-605-5p	81.1414	NM_024010
MTRR	hsa-miR-548c-3p	80.2029	NM_024010

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Motifs and transcription factors (TFs) regulating MTRR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTRR	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MTRR	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MTRR	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MTRR	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MTRR	"Cyanocobalamin"	DB00115	small molecule
MTRR	"Methionine"	DB00134	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."