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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MTCH2

Summary for MTCH2

Gene information	Gene symbol	MTCH2
	Ensembl ID	ENSG00000285121
	Entrez ID	23788
	Gene name	mitochondrial carrier 2
	Synonyms	SLC25A50
	Gene type	protein_coding
	UniProtAcc	Q9Y6C9

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Dataset with differentially expressed gene: MTCH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.477117	3.61e-03
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.551562	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.372797	2.82e-26
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.467321	3.23e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.347209	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.318445	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.423679	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.497458	1.64e-42
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.476458	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.360278	1.00e-24
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.331204	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.469923	0.00e+00

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Expression of MTCH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTCH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTCH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTCH2	hsa-miR-4446-5p	98.8728	NM_001317233
MTCH2	hsa-miR-2116-3p	97.1332	NM_001317231
MTCH2	hsa-miR-6878-5p	96.9006	NM_001317231
MTCH2	hsa-miR-3133	94.909	NM_001317231
MTCH2	hsa-miR-150-5p	93.7877	NM_001317231
MTCH2	hsa-miR-153-5p	92.6887	NM_001317231
MTCH2	hsa-miR-30c-2-3p	92.5097	NM_001317231
MTCH2	hsa-miR-6788-5p	92.5097	NM_001317231
MTCH2	hsa-miR-30c-1-3p	92.5097	NM_001317231
MTCH2	hsa-miR-3915	92.4874	NM_001317231
MTCH2	hsa-miR-580-5p	91.6975	NM_001317231
MTCH2	hsa-miR-190a-3p	90.8264	NM_001317231
MTCH2	hsa-miR-219a-1-3p	89.5259	NM_001317231
MTCH2	hsa-miR-5006-3p	89.0885	NM_001317231
MTCH2	hsa-miR-4755-5p	89.0885	NM_001317231
MTCH2	hsa-miR-182-5p	88.9753	NM_001317233
MTCH2	hsa-miR-3163	88.3205	NM_001317233
MTCH2	hsa-miR-5011-5p	87.7343	NM_001317231
MTCH2	hsa-miR-3672	86.8623	NM_001317231
MTCH2	hsa-miR-6864-3p	86.8623	NM_001317231
MTCH2	hsa-miR-629-3p	86.8163	NM_001317231
MTCH2	hsa-miR-4713-5p	85.244	NM_001317231
MTCH2	hsa-miR-5680	84.6741	NM_001317233
MTCH2	hsa-miR-6814-5p	84.1931	NM_001317233
MTCH2	hsa-miR-887-5p	80.8485	NM_001317231
MTCH2	hsa-miR-5094	80.139	NM_001317231

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Motifs and transcription factors (TFs) regulating MTCH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTCH2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MTCH2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MTCH2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MTCH2	transfac_pro__M00652	NRF1 (directAnnotation).
MTCH2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MTCH2	transfac_pro__M04866	HDAC2 (directAnnotation).
MTCH2	metacluster_55.5	ZNF541 (directAnnotation).
MTCH2	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
MTCH2	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."