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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)

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Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: MT-ATP6

Summary for MT-ATP6

Gene informationGene symbol

MT-ATP6

Ensembl ID

ENSG00000198899

Entrez ID

4508

Gene nameATP synthase F0 subunit 6
SynonymsATP6|ATPase-6|MTATP6|RP|Su6m
Gene typeprotein_coding
UniProtAcc

P00846


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Dataset with differentially expressed gene: MT-ATP6

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells1.227950.00e+00

GSE138267

CDXTumor tissueLung cancerSmall cell lung cancer (SCLC)ChemotherapyNANAMalignant cells-0.3606550.00e+00

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells2.887930.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostMono/Macro-0.6218750.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostNK cells-0.619860.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostpDCs-1.185213.34e-08

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostPlasma cells-0.9630931.13e-26

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostB cells-0.6450260.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD4+ T cells-0.9974360.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD8+ T cells-0.4906190.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells-0.4733170.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells-0.4456070.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells-0.6276560.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells-0.265180.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD8+ T cells-0.3041064.91e-14

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostMono/Macro0.4209164.46e-29

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD4+ T cells-0.3521971.33e-14

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostPlasma cells-0.7614233.66e-25

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprePlasma cells0.6989730.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.3542462.73e-04

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.4232332.89e-31

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprepDCs1.136814.55e-02

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells0.8200470.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro0.7337191.20e-27

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.3155625.08e-29

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD4+ T cells0.4230770.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD8+ T cells0.281010.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostB cells0.3466060.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD8+ T cells0.5378980.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells0.4063810.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreNK cells0.6437410.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreB cells0.3747050.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostB cells0.3112672.20e-14

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD8+ T cells-0.2791751.78e-28

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells-0.2804760.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprePlasma cells-0.2810481.05e-10

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD8+ T cells-0.3473950.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro0.7535120.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postcDCs-0.5163391.68e-03

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preCD8+ T cells0.2546070.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preNK cells0.4598470.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro0.5422055.24e-10

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells-0.3193687.56e-04

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAErythrocytes-1.103977.72e-41

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMast cells0.9552367.78e-04

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells0.6794873.31e-34

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postNK cells0.3019590.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells0.6318880.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells0.2565520.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD4+ T cells0.639120.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.2608366.98e-08

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMono/Macro0.2729670.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.3283030.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMono/Macro-0.4580430.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostcDCs-0.7233451.90e-05

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMalignant cells-0.6425813.83e-26

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostCD4+ T cells-0.4952796.33e-06

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostNK cells-0.5457851.69e-40

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostCD8+ T cells-0.7064350.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells-0.4275882.21e-17

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.7436920.00e+00

GSE161195

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapyDARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)postMalignant cells-0.3717531.40e-45

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.5893660.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells0.3809790.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostErythrocytes-1.009270.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostB cells1.784412.77e-06

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.4307110.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells0.3138310.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-1.471731.40e-07

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreErythrocytes-0.5048041.15e-22

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreNK cells0.2979362.00e-10

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD8+ T cells-0.3683382.54e-06

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostNK cells-0.3903311.47e-06

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD8+ T cells-0.3179072.25e-02

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD4+ T cells-0.44751.20e-02

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMalignant cells-0.5860.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.4933650.00e+00

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells0.3604631.07e-32

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.8621030.00e+00

GSE104987

MCF7 cell lineCell lineBreast cancerER+ breast cancerTargeted therapyKDM5-C70NAMalignant cells0.3566983.56e-34

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.6614020.00e+00

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-1.009210.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD8+ T cells-0.4851670.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostNK cells-0.2623541.18e-06

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD4+ T cells-0.4524273.15e-08

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreMalignant cells-0.9407890.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreB cells-0.2953151.83e-21

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreCD8+ T cells-0.2643685.07e-41

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.5203720.00e+00

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-0.2731650.00e+00

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells0.8229360.00e+00

GSE164897_VemTra

A375 cell lineCell lineMelanomaB+E2:E57RAFV600E-mutant melanomaTargeted therapyvemurafenib + trametinibNAMalignant cells1.160840.00e+00

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Expression of MT-ATP6 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to MT-ATP6

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MT-ATP6

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating MT-ATP6

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
MT-ATP6"Estradiol acetate"

DB13952

small molecule
MT-ATP6"Estradiol benzoate"

DB13953

small molecule
MT-ATP6"Estradiol cypionate"

DB13954

small molecule
MT-ATP6"Estradiol dienanthate"

DB13955

small molecule
MT-ATP6"Estradiol valerate"

DB13956

small molecule
MT-ATP6"Estradiol"

DB00783

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."