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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MSX1

Summary for MSX1

Gene information	Gene symbol	MSX1
	Ensembl ID	ENSG00000163132
	Entrez ID	4487
	Gene name	msh homeobox 1
	Synonyms	HOX7\|HYD1\|OFC5
	Gene type	protein_coding
	UniProtAcc	P28360

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Dataset with differentially expressed gene: MSX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.36113	0.00e+00

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Expression of MSX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MSX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MSX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MSX1	hsa-miR-607	95.7998	NM_002448
MSX1	hsa-miR-3121-3p	95.7048	NM_002448
MSX1	hsa-miR-144-3p	95.5702	NM_002448
MSX1	hsa-miR-4282	95.0352	NM_002448
MSX1	hsa-miR-5692c	93.916	NM_002448
MSX1	hsa-miR-5692b	93.916	NM_002448
MSX1	hsa-miR-4775	90.9652	NM_002448
MSX1	hsa-miR-3144-5p	90.0558	NM_002448
MSX1	hsa-miR-7-2-3p	88.5508	NM_002448
MSX1	hsa-miR-7-1-3p	88.5508	NM_002448
MSX1	hsa-miR-656-3p	88.3857	NM_002448
MSX1	hsa-miR-3671	86.3131	NM_002448
MSX1	hsa-miR-7156-5p	85.7251	NM_002448
MSX1	hsa-miR-513a-3p	85.1825	NM_002448
MSX1	hsa-miR-513c-3p	85.1825	NM_002448
MSX1	hsa-miR-3606-3p	84.7125	NM_002448
MSX1	hsa-miR-5088-3p	84.1736	NM_002448
MSX1	hsa-miR-7705	84.0798	NM_002448
MSX1	hsa-miR-5579-3p	83.948	NM_002448
MSX1	hsa-miR-4273	82.0243	NM_002448
MSX1	hsa-miR-10399-5p	81.6267	NM_002448
MSX1	hsa-miR-6504-3p	81.6267	NM_002448
MSX1	hsa-miR-190b-3p	81.1573	NM_002448
MSX1	hsa-miR-101-3p	80.4529	NM_002448

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Motifs and transcription factors (TFs) regulating MSX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MSX1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MSX1	hdpi__ETV4	ETV4 (directAnnotation).
MSX1	cisbp__M02645	ETS1 (directAnnotation).
MSX1	transfac_pro__M06156	ZNF75D (directAnnotation).
MSX1	hdpi__FLI1	FLI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."