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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MSRB3

Summary for MSRB3

Gene information	Gene symbol	MSRB3
	Ensembl ID	ENSG00000174099
	Entrez ID	253827
	Gene name	methionine sulfoxide reductase B3
	Synonyms	DFNB74\|DKFZp686C1178\|FLJ36866
	Gene type	protein_coding
	UniProtAcc	Q8IXL7

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Dataset with differentially expressed gene: MSRB3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.318928	1.60e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.436722	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.276313	9.38e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.328628	5.86e-21

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Expression of MSRB3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MSRB3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MSRB3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MSRB3	hsa-miR-1305	98.5858	NM_001031679
MSRB3	hsa-miR-335-3p	98.4664	NM_001031679
MSRB3	hsa-miR-6128	97.7836	NM_001031679
MSRB3	hsa-miR-340-5p	96.3197	NM_001031679
MSRB3	hsa-miR-4503	94.7999	NM_001031679
MSRB3	hsa-miR-3680-3p	94.5798	NM_001031679
MSRB3	hsa-miR-548av-3p	94.4638	NM_001031679
MSRB3	hsa-miR-6728-3p	94.3648	NM_001031679
MSRB3	hsa-miR-6124	94.1042	NM_001031679
MSRB3	hsa-miR-938	93.9966	NM_001031679
MSRB3	hsa-miR-874-3p	93.666	NM_001031679
MSRB3	hsa-miR-524-5p	93.539	NM_001031679
MSRB3	hsa-miR-520d-5p	93.539	NM_001031679
MSRB3	hsa-miR-3163	93.2096	NM_001031679
MSRB3	hsa-miR-4795-3p	93.0271	NM_001031679
MSRB3	hsa-miR-3148	92.5763	NM_001031679
MSRB3	hsa-miR-3128	91.5755	NM_001031679
MSRB3	hsa-miR-607	91.5511	NM_001031679
MSRB3	hsa-miR-7976	91.4758	NM_001031679
MSRB3	hsa-miR-153-5p	91.3863	NM_001031679
MSRB3	hsa-miR-504-3p	90.1511	NM_001031679
MSRB3	hsa-miR-550a-3p	89.9702	NM_001031679
MSRB3	hsa-miR-548aj-5p	89.9011	NM_001031679
MSRB3	hsa-miR-548x-5p	89.9011	NM_001031679
MSRB3	hsa-miR-548f-5p	89.9011	NM_001031679
MSRB3	hsa-miR-548g-5p	89.9011	NM_001031679
MSRB3	hsa-miR-196a-3p	89.5668	NM_001031679
MSRB3	hsa-miR-200c-5p	89.0841	NM_001031679
MSRB3	hsa-miR-578	88.828	NM_001031679
MSRB3	hsa-miR-497-3p	88.7762	NM_001031679
MSRB3	hsa-miR-302c-5p	88.4519	NM_001031679
MSRB3	hsa-miR-33b-5p	88.1951	NM_001031679
MSRB3	hsa-miR-33a-5p	88.1951	NM_001031679
MSRB3	hsa-miR-587	87.9011	NM_001031679
MSRB3	hsa-miR-137-3p	87.4695	NM_001031679
MSRB3	hsa-miR-1299	87.446	NM_001031679
MSRB3	hsa-miR-643	86.5144	NM_001031679
MSRB3	hsa-miR-4319	86.4716	NM_001031679
MSRB3	hsa-miR-3173-5p	86.2714	NM_001031679
MSRB3	hsa-miR-18a-3p	86.2344	NM_001031679
MSRB3	hsa-miR-4666a-3p	86.0531	NM_001031679
MSRB3	hsa-miR-10527-5p	85.7097	NM_001031679
MSRB3	hsa-miR-6799-3p	84.6167	NM_001031679
MSRB3	hsa-miR-875-3p	84.0086	NM_001031679
MSRB3	hsa-miR-19a-5p	83.4034	NM_001031679
MSRB3	hsa-miR-19b-1-5p	83.4034	NM_001031679
MSRB3	hsa-miR-19b-2-5p	83.4034	NM_001031679
MSRB3	hsa-miR-5582-5p	83.1725	NM_001031679
MSRB3	hsa-miR-2052	82.9946	NM_001031679
MSRB3	hsa-miR-125b-5p	81.8862	NM_001031679

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Motifs and transcription factors (TFs) regulating MSRB3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MSRB3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MSRB3	hdpi__TP73	TP73 (directAnnotation).
MSRB3	jaspar__MA1483.2	ELF2 (directAnnotation).
MSRB3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MSRB3	transfac_pro__M04826	EP300 (directAnnotation).
MSRB3	hdpi__ETV4	ETV4 (directAnnotation).
MSRB3	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MSRB3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
MSRB3	cisbp__M08198	ELF1 (directAnnotation).
MSRB3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MSRB3	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
MSRB3	jaspar__MA0748.2	YY2 (directAnnotation).
MSRB3	transfac_pro__M01298	MECP2 (directAnnotation).
MSRB3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
MSRB3	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
MSRB3	metacluster_182.10	ZFX (directAnnotation).
MSRB3	transfac_pro__M00492	STAT1 (directAnnotation).
MSRB3	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MSRB3	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MSRB3	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MSRB3	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
MSRB3	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MSRB3	transfac_pro__M04950	EGR1 (directAnnotation).
MSRB3	transfac_pro__M06032	ZNF727 (directAnnotation).
MSRB3	transfac_pro__M05706	ZNF20 (directAnnotation).
MSRB3	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
MSRB3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
MSRB3	hdpi__ELF2	ELF2 (directAnnotation).
MSRB3	swissregulon__hs__ELK1	ELK1 (directAnnotation).
MSRB3	metacluster_183.4	ETS1 (inferredBy_Orthology).
MSRB3	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
MSRB3	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."