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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MSR1

Summary for MSR1

Gene information	Gene symbol	MSR1
	Ensembl ID	ENSG00000038945
	Entrez ID	4481
	Gene name	macrophage scavenger receptor 1
	Synonyms	CD204\|SCARA1\|SR-A\|SR-AI\|SR-AII\|SR-AIII
	Gene type	protein_coding
	UniProtAcc	P21757

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Dataset with differentially expressed gene: MSR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.294506	7.01e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.398342	3.15e-23
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.398867	1.06e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.72326	0.00e+00

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Expression of MSR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MSR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MSR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MSR1	hsa-miR-5011-5p	100	NM_002445
MSR1	hsa-miR-190a-3p	100	NM_002445
MSR1	hsa-miR-3923	99.5205	NM_138716
MSR1	hsa-miR-8084	99.2112	NM_138716
MSR1	hsa-miR-34a-3p	96.7986	NM_138716
MSR1	hsa-miR-4528	96.3036	NM_138716
MSR1	hsa-miR-6853-3p	95.8839	NM_002445
MSR1	hsa-miR-1290	95.6132	NM_138715
MSR1	hsa-miR-633	94.5259	NM_138716
MSR1	hsa-miR-4703-5p	92.7656	NM_138715
MSR1	hsa-miR-9986	91.9085	NM_002445
MSR1	hsa-miR-1294	91.9085	NM_002445
MSR1	hsa-miR-4524a-3p	91.6234	NM_138716
MSR1	hsa-miR-4795-3p	91.3856	NM_138716
MSR1	hsa-miR-4521	90.2585	NM_002445
MSR1	hsa-miR-3942-5p	89.1221	NM_138715
MSR1	hsa-miR-3662	89.1219	NM_138716
MSR1	hsa-miR-1278	88.3304	NM_138716
MSR1	hsa-miR-4652-3p	88.245	NM_138716
MSR1	hsa-miR-7110-5p	87.708	NM_002445
MSR1	hsa-miR-1257	87.422	NM_138716
MSR1	hsa-miR-4740-5p	87.4153	NM_138716
MSR1	hsa-miR-32-5p	87.3072	NM_138716
MSR1	hsa-miR-92b-3p	87.3072	NM_138716
MSR1	hsa-miR-92a-3p	87.3072	NM_138716
MSR1	hsa-miR-4670-3p	87.0731	NM_138715
MSR1	hsa-miR-377-3p	87.032	NM_002445
MSR1	hsa-miR-6770-5p	86.803	NM_002445
MSR1	hsa-miR-4267	86.6166	NM_002445
MSR1	hsa-miR-520d-5p	86.5884	NM_138716
MSR1	hsa-miR-524-5p	86.5884	NM_138716
MSR1	hsa-miR-5582-5p	86.2077	NM_138716
MSR1	hsa-miR-363-3p	85.9507	NM_138716
MSR1	hsa-miR-367-3p	85.9507	NM_138716
MSR1	hsa-miR-25-3p	85.9507	NM_138716
MSR1	hsa-miR-3163	85.8677	NM_138715
MSR1	hsa-miR-198	85.0331	NM_002445
MSR1	hsa-miR-543	84.6064	NM_138716
MSR1	hsa-miR-548c-3p	84.4887	NM_002445
MSR1	hsa-miR-126-5p	84.3332	NM_138716
MSR1	hsa-miR-12130	84.3192	NM_138716
MSR1	hsa-miR-424-3p	83.9777	NM_002445
MSR1	hsa-miR-4801	83.6136	NM_138716
MSR1	hsa-miR-8068	83.5658	NM_138716
MSR1	hsa-miR-4698	83.5443	NM_138716
MSR1	hsa-miR-4481	83.3919	NM_002445
MSR1	hsa-miR-6824-3p	83.3391	NM_002445
MSR1	hsa-miR-6764-3p	83.3391	NM_002445
MSR1	hsa-miR-3617-3p	83.0784	NM_138716
MSR1	hsa-miR-4500	82.975	NM_002445

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Motifs and transcription factors (TFs) regulating MSR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MSR1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
MSR1	tfdimers__MD00545	ETS1; SOX10 (directAnnotation).
MSR1	tfdimers__MD00515	ARID3A; KLF4 (directAnnotation).
MSR1	transfac_pro__M06723	ZNF492 (directAnnotation).
MSR1	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
MSR1	tfdimers__MD00186	NFATC3; SPI1 (directAnnotation).
MSR1	metacluster_22.13	MAFK (inferredBy_Orthology).
MSR1	metacluster_22.32	NFE2L2 (directAnnotation).
MSR1	transfac_pro__M06504	ZFP62 (directAnnotation).
MSR1	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
MSR1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
MSR1	transfac_pro__M05877	ZNF467 (inferredBy_Orthology).
MSR1	tfdimers__MD00208	IRF1; LTF (directAnnotation).
MSR1	transfac_pro__M06985	BATF3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."