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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MSL1

Summary for MSL1

Gene information	Gene symbol	MSL1
	Ensembl ID	ENSG00000188895
	Entrez ID	339287
	Gene name	MSL complex subunit 1
	Synonyms	DKFZp686P24239\|hMSL1\|MSL-1
	Gene type	protein_coding
	UniProtAcc	Q68DK7

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Dataset with differentially expressed gene: MSL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.255497	8.27e-11
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.329281	6.22e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.259151	1.45e-15

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Expression of MSL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MSL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MSL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MSL1	hsa-miR-8485	97.6935	NM_001012241
MSL1	hsa-miR-8068	97.3133	NM_001012241
MSL1	hsa-miR-188-3p	96.596	NM_001012241
MSL1	hsa-miR-4786-5p	94.5622	NM_001012241
MSL1	hsa-miR-4680-5p	93.8717	NM_001012241
MSL1	hsa-miR-337-3p	91.3647	NM_001012241
MSL1	hsa-miR-4279	90.7758	NM_001012241
MSL1	hsa-miR-302e	90.5951	NM_001012241
MSL1	hsa-miR-128-3p	89.6837	NM_001012241
MSL1	hsa-miR-216a-3p	89.6837	NM_001012241
MSL1	hsa-miR-4753-3p	88.0943	NM_001012241
MSL1	hsa-miR-3942-3p	87.8178	NM_001012241
MSL1	hsa-miR-302a-3p	87.6956	NM_001012241
MSL1	hsa-miR-302b-3p	87.6956	NM_001012241
MSL1	hsa-miR-302c-3p	87.6956	NM_001012241
MSL1	hsa-miR-302d-3p	87.6956	NM_001012241
MSL1	hsa-miR-5004-5p	87.4069	NM_001012241
MSL1	hsa-miR-6873-3p	86.9604	NM_001012241
MSL1	hsa-miR-6836-5p	86.6935	NM_001012241
MSL1	hsa-miR-6132	86.6935	NM_001012241
MSL1	hsa-miR-3681-3p	86.2679	NM_001012241
MSL1	hsa-miR-5584-5p	86.1922	NM_001012241
MSL1	hsa-miR-27b-3p	85.4453	NM_001012241
MSL1	hsa-miR-27a-3p	85.4453	NM_001012241
MSL1	hsa-miR-9985	85.4453	NM_001012241
MSL1	hsa-miR-627-3p	84.9343	NM_001012241
MSL1	hsa-miR-372-3p	84.6613	NM_001012241
MSL1	hsa-miR-520a-3p	84.6613	NM_001012241
MSL1	hsa-miR-373-3p	84.6613	NM_001012241
MSL1	hsa-miR-520d-3p	84.6613	NM_001012241
MSL1	hsa-miR-520e-3p	84.6613	NM_001012241
MSL1	hsa-miR-520c-3p	84.6613	NM_001012241
MSL1	hsa-miR-520b-3p	84.6613	NM_001012241
MSL1	hsa-miR-466	84.6587	NM_001012241
MSL1	hsa-miR-4653-3p	83.4137	NM_001012241
MSL1	hsa-miR-3679-3p	83.3833	NM_001012241
MSL1	hsa-miR-570-3p	82.5225	NM_001012241
MSL1	hsa-miR-370-5p	82.3552	NM_001012241
MSL1	hsa-miR-449b-3p	82.1634	NM_001012241
MSL1	hsa-miR-135a-2-3p	81.9555	NM_001012241
MSL1	hsa-miR-135b-3p	81.9555	NM_001012241
MSL1	hsa-miR-7152-3p	81.8724	NM_001012241
MSL1	hsa-miR-6833-3p	80.8404	NM_001012241
MSL1	hsa-miR-4452	80.1561	NM_001012241
MSL1	hsa-miR-3977	80.005	NM_001012241

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Motifs and transcription factors (TFs) regulating MSL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MSL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MSL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MSL1	metacluster_7.13	ZFX (directAnnotation).
MSL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MSL1	cisbp__M00968	MTF2 (directAnnotation).
MSL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MSL1	cisbp__M00341	PAX6 (directAnnotation).
MSL1	metacluster_198.3	ZFP64 (directAnnotation).
MSL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MSL1	cisbp__M00788	ZFY (inferredBy_Orthology).
MSL1	hdpi__ZNF304	ZNF304 (directAnnotation).
MSL1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MSL1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MSL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MSL1	transfac_pro__M01199	TRIM28 (directAnnotation).
MSL1	metacluster_151.2	ZNF23 (directAnnotation).
MSL1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MSL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MSL1	transfac_pro__M03806	ZBTB7C (directAnnotation).
MSL1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MSL1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
MSL1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
MSL1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
MSL1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MSL1	transfac_pro__M05785	ZNF48 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."