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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MS4A4A

Summary for MS4A4A

Gene information	Gene symbol	MS4A4A
	Ensembl ID	ENSG00000110079
	Entrez ID	51338
	Gene name	membrane spanning 4-domains A4A
	Synonyms	CD20L1\|MS4A4\|MS4A7
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MS4A4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.306422	8.55e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.693703	3.26e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.52368	0.00e+00

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Expression of MS4A4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MS4A4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MS4A4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MS4A4A	hsa-miR-587	90.3376	NM_001243266
MS4A4A	hsa-miR-7113-5p	89.7576	NM_001243266
MS4A4A	hsa-miR-1272	89.162	NM_001243266
MS4A4A	hsa-miR-3194-3p	87.7506	NM_001243266
MS4A4A	hsa-miR-4668-5p	84.4762	NM_001243266
MS4A4A	hsa-miR-2467-5p	83.5197	NM_001243266
MS4A4A	hsa-miR-6883-5p	83.4919	NM_001243266
MS4A4A	hsa-miR-6785-5p	82.2701	NM_001243266
MS4A4A	hsa-miR-4728-5p	82.2701	NM_001243266
MS4A4A	hsa-miR-19b-2-5p	80.576	NM_001243266
MS4A4A	hsa-miR-19a-5p	80.576	NM_001243266
MS4A4A	hsa-miR-19b-1-5p	80.576	NM_001243266

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Motifs and transcription factors (TFs) regulating MS4A4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MS4A4A	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
MS4A4A	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
MS4A4A	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
MS4A4A	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
MS4A4A	metacluster_198.1	ZNF439 (directAnnotation).
MS4A4A	taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr	PITX1; TBX21 (directAnnotation).
MS4A4A	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."