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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MS4A1

Summary for MS4A1

Gene information	Gene symbol	MS4A1
	Ensembl ID	ENSG00000156738
	Entrez ID	931
	Gene name	membrane spanning 4-domains A1
	Synonyms	B1\|Bp35\|CD20\|FMC7
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MS4A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	-0.255747	1.78e-15
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.315611	6.44e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.546548	7.02e-23
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.278193	3.38e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	2.14619	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.08449	9.25e-04
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.947001	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.970806	0.00e+00

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Expression of MS4A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MS4A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MS4A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MS4A1	hsa-miR-4534	94.2089	NM_021950
MS4A1	hsa-miR-944	93.8398	NM_021950
MS4A1	hsa-miR-4662a-3p	93.1231	NM_021950
MS4A1	hsa-miR-8082	92.66	NM_021950
MS4A1	hsa-miR-33a-3p	91.7966	NM_021950
MS4A1	hsa-miR-4262	90.0403	NM_021950
MS4A1	hsa-miR-6780a-5p	89.3633	NM_021950
MS4A1	hsa-miR-190a-3p	87.9046	NM_021950
MS4A1	hsa-miR-6779-5p	87.2958	NM_021950
MS4A1	hsa-miR-1273h-5p	87.2958	NM_021950
MS4A1	hsa-miR-3689b-3p	87.2958	NM_021950
MS4A1	hsa-miR-3689c	87.2958	NM_021950
MS4A1	hsa-miR-30b-3p	87.2958	NM_021950
MS4A1	hsa-miR-3689a-3p	87.2958	NM_021950
MS4A1	hsa-miR-181b-5p	87.0279	NM_021950
MS4A1	hsa-miR-181d-5p	87.0279	NM_021950
MS4A1	hsa-miR-181c-5p	87.0279	NM_021950
MS4A1	hsa-miR-181a-5p	87.0279	NM_021950
MS4A1	hsa-miR-205-3p	86.6174	NM_021950
MS4A1	hsa-miR-12130	86.591	NM_021950
MS4A1	hsa-miR-6839-3p	86.4776	NM_021950
MS4A1	hsa-miR-1322	86.0675	NM_021950
MS4A1	hsa-miR-3150b-3p	85.6181	NM_021950
MS4A1	hsa-miR-4784	85.6181	NM_021950
MS4A1	hsa-miR-576-3p	84.9956	NM_021950
MS4A1	hsa-miR-4694-3p	83.6856	NM_021950
MS4A1	hsa-miR-6715b-3p	83.59	NM_021950
MS4A1	hsa-miR-4684-5p	83.3817	NM_021950
MS4A1	hsa-miR-4496	83.1555	NM_021950
MS4A1	hsa-miR-1258	82.6135	NM_021950
MS4A1	hsa-miR-6079	82.5865	NM_021950
MS4A1	hsa-miR-4531	82.5031	NM_021950
MS4A1	hsa-miR-875-3p	80.4539	NM_021950

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Motifs and transcription factors (TFs) regulating MS4A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MS4A1	transfac_pro__M05349	SNAI3 (directAnnotation).
MS4A1	transfac_pro__M05930	ZNF286A (directAnnotation).
MS4A1	metacluster_16.7	SOX10; SOX11; SOX14; SOX14; SOX15; SOX18; SOX2; SOX2; SOX21; SOX21; SOX21; SOX7; SOX7; SOX7; SOX8; SOX8; SOX9; SRY (directAnnotation). SOX1; SOX1; SOX10; SOX21; SOX3 (inferredBy_Orthology).
MS4A1	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
MS4A1	transfac_pro__M02082	ISL2 (directAnnotation).
MS4A1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MS4A1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
MS4A1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MS4A1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
MS4A1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MS4A1	transfac_pro__M06173	ZNF85 (directAnnotation).
MS4A1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
MS4A1	transfac_pro__M04887	TCF12 (directAnnotation).
MS4A1	metacluster_79.12	ZNF257 (directAnnotation).
MS4A1	taipale_cyt_meth__LHX5_NTCGTTAN_FL_meth	LHX5 (directAnnotation).
MS4A1	metacluster_55.5	ZNF541 (directAnnotation).
MS4A1	tfdimers__MD00218	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM; ELF1 (directAnnotation).
MS4A1	transfac_pro__M06609	ZKSCAN4 (directAnnotation).
MS4A1	transfac_pro__M06895	ZFP3 (inferredBy_Orthology).
MS4A1	transfac_pro__M06971	ZNF521 (directAnnotation).
MS4A1	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
MS4A1	metacluster_172.8	SIX1 (directAnnotation).
MS4A1	tfdimers__MD00336	IRF8; STAT1 (directAnnotation).
MS4A1	transfac_pro__M06223	ZNF155 (directAnnotation).
MS4A1	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
MS4A1	swissregulon__hs__HSF2	HSF2 (directAnnotation).
MS4A1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MS4A1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
MS4A1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MS4A1	transfac_pro__M06311	ZNF568 (directAnnotation).
MS4A1	transfac_pro__M02830	ZSCAN26 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MS4A1	"Ibritumomab tiuxetan"	DB00078	biotech
MS4A1	"Mosunetuzumab"	DB15434	biotech
MS4A1	"Obinutuzumab"	DB08935	biotech
MS4A1	"Ocrelizumab"	DB11988	biotech
MS4A1	"Odronextamab"	DB16684	biotech
MS4A1	"Ofatumumab"	DB06650	biotech
MS4A1	"Rituximab"	DB00073	biotech
MS4A1	"Technetium Tc-99m nofetumomab merpentan"	DB09336	small molecule
MS4A1	"Tositumomab"	DB00081	biotech
MS4A1	"Ublituximab"	DB11850	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."