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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MRS2

Summary for MRS2

Gene information	Gene symbol	MRS2
	Ensembl ID	ENSG00000124532
	Entrez ID	57380
	Gene name	magnesium transporter MRS2
	Synonyms	MRS2L
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MRS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.365725	0.00e+00

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Expression of MRS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MRS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MRS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MRS2	hsa-miR-381-3p	97.0664	NM_001286266
MRS2	hsa-miR-300	97.0664	NM_001286266
MRS2	hsa-miR-3163	94.3223	NM_001286264
MRS2	hsa-miR-466	93.9381	NM_001286265
MRS2	hsa-miR-8065	93.4854	NM_001286266
MRS2	hsa-miR-190a-5p	93.3409	NM_001286266
MRS2	hsa-miR-190b-5p	93.3409	NM_001286266
MRS2	hsa-miR-6733-3p	93.2413	NM_001286265
MRS2	hsa-miR-520e-5p	92.98	NM_001286266
MRS2	hsa-miR-7153-5p	92.1943	NM_001286266
MRS2	hsa-miR-146b-5p	92.1943	NM_001286266
MRS2	hsa-miR-146a-5p	92.1943	NM_001286266
MRS2	hsa-miR-4500	91.0741	NM_001286264
MRS2	hsa-miR-499b-5p	89.6248	NM_001286266
MRS2	hsa-let-7f-5p	89.43	NM_001286264
MRS2	hsa-let-7c-5p	89.43	NM_001286264
MRS2	hsa-let-7g-5p	89.43	NM_001286264
MRS2	hsa-let-7a-5p	89.43	NM_001286264
MRS2	hsa-miR-98-5p	89.43	NM_001286264
MRS2	hsa-let-7b-5p	89.43	NM_001286264
MRS2	hsa-let-7i-5p	89.43	NM_001286264
MRS2	hsa-let-7e-5p	89.43	NM_001286264
MRS2	hsa-let-7d-5p	87.9579	NM_001286264
MRS2	hsa-miR-4458	87.9579	NM_001286264
MRS2	hsa-miR-548c-3p	87.8845	NM_001286266
MRS2	hsa-miR-4795-3p	87.606	NM_001286266
MRS2	hsa-miR-1284	86.689	NM_001286266
MRS2	hsa-miR-3924	85.0293	NM_001286266
MRS2	hsa-miR-652-5p	84.6762	NM_001286265
MRS2	hsa-miR-1299	84.4017	NM_001286266
MRS2	hsa-miR-194-5p	83.5348	NM_001286266
MRS2	hsa-miR-4711-3p	83.4236	NM_001286265
MRS2	hsa-miR-4789-3p	83.1625	NM_001286265
MRS2	hsa-miR-524-5p	82.4905	NM_001286266
MRS2	hsa-miR-520d-5p	82.4905	NM_001286266
MRS2	hsa-miR-3660	82.3007	NM_001286265
MRS2	hsa-miR-4526	82.3007	NM_001286265
MRS2	hsa-miR-3613-3p	81.3953	NM_001286266
MRS2	hsa-miR-4633-5p	81.2117	NM_001286266
MRS2	hsa-miR-2115-3p	81.0054	NM_001286266
MRS2	hsa-miR-208a-5p	80.2607	NM_001286266
MRS2	hsa-miR-208b-5p	80.2607	NM_001286266

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Motifs and transcription factors (TFs) regulating MRS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MRS2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MRS2	transfac_pro__M04950	EGR1 (directAnnotation).
MRS2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MRS2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MRS2	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."