Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MRPL44

Summary for MRPL44

Gene information	Gene symbol	MRPL44
	Ensembl ID	ENSG00000135900
	Entrez ID	65080
	Gene name	mitochondrial ribosomal protein L44
	Synonyms	FLJ12701\|FLJ13990
	Gene type	protein_coding
	UniProtAcc	Q9H9J2

Top

Dataset with differentially expressed gene: MRPL44

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.268983	1.47e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.290978	1.23e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.660743	0.00e+00

Top

Expression of MRPL44 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MRPL44

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MRPL44

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MRPL44	hsa-miR-1284	93.0934	NM_022915
MRPL44	hsa-miR-513b-3p	92.8962	NM_022915
MRPL44	hsa-miR-450b-5p	90.4164	NM_022915
MRPL44	hsa-miR-9983-3p	90.0373	NM_022915
MRPL44	hsa-let-7b-3p	89.2243	NM_022915
MRPL44	hsa-let-7a-3p	89.2243	NM_022915
MRPL44	hsa-let-7f-1-3p	89.2243	NM_022915
MRPL44	hsa-miR-98-3p	89.2243	NM_022915
MRPL44	hsa-miR-3120-3p	88.1911	NM_022915
MRPL44	hsa-miR-6715a-3p	87.6197	NM_022915
MRPL44	hsa-miR-514b-5p	87.5284	NM_022915
MRPL44	hsa-miR-513c-5p	87.5284	NM_022915
MRPL44	hsa-miR-3613-3p	87.5247	NM_022915
MRPL44	hsa-miR-129-5p	87.0143	NM_022915
MRPL44	hsa-miR-4666a-3p	86.7348	NM_022915
MRPL44	hsa-miR-548aw	86.3673	NM_022915

Page: 1

Top

Motifs and transcription factors (TFs) regulating MRPL44

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MRPL44	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MRPL44	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MRPL44	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MRPL44	jaspar__MA1483.2	ELF2 (directAnnotation).
MRPL44	cisbp__M00808	MYPOP (inferredBy_Orthology).
MRPL44	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
MRPL44	hdpi__TP73	TP73 (directAnnotation).
MRPL44	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
MRPL44	jaspar__MA1957.1	ELK1 (directAnnotation).
MRPL44	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MRPL44	jaspar__MA1708.1	ETV7 (directAnnotation).
MRPL44	hdpi__ELF2	ELF2 (directAnnotation).
MRPL44	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MRPL44	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
MRPL44	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MRPL44	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MRPL44	jaspar__MA1932.1	HOXB13 (directAnnotation).
MRPL44	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MRPL44	metacluster_81.7	CREB1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."