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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MRPL19

Summary for MRPL19

Gene information	Gene symbol	MRPL19
	Ensembl ID	ENSG00000115364
	Entrez ID	9801
	Gene name	mitochondrial ribosomal protein L19
	Synonyms	KIAA0104\|MRP-L15\|RLX1\|RPML15
	Gene type	protein_coding
	UniProtAcc	P49406

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Dataset with differentially expressed gene: MRPL19

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.438229	5.07e-36
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.464076	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.274908	4.93e-17
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.542876	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.521181	2.24e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.570313	6.17e-44
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.388547	7.84e-15
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.365461	5.49e-42
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.433883	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.338457	0.00e+00

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Expression of MRPL19 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MRPL19

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MRPL19

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MRPL19	hsa-miR-12136	98.0351	NM_014763
MRPL19	hsa-miR-3646	96.7523	NM_014763
MRPL19	hsa-miR-616-5p	95.771	NM_014763
MRPL19	hsa-miR-373-5p	95.771	NM_014763
MRPL19	hsa-miR-371b-5p	95.771	NM_014763
MRPL19	hsa-miR-5011-5p	95.1894	NM_014763
MRPL19	hsa-miR-4677-3p	93.0624	NM_014763
MRPL19	hsa-miR-345-3p	92.8731	NM_014763
MRPL19	hsa-miR-1283	92.4166	NM_014763
MRPL19	hsa-miR-2116-5p	92.029	NM_014763
MRPL19	hsa-miR-95-5p	91.8392	NM_014763
MRPL19	hsa-miR-4753-3p	91.4737	NM_014763
MRPL19	hsa-miR-4311	91.2553	NM_014763
MRPL19	hsa-miR-513b-5p	90.5242	NM_014763
MRPL19	hsa-miR-552-5p	89.6685	NM_014763
MRPL19	hsa-miR-3928-3p	89.2473	NM_014763
MRPL19	hsa-miR-3685	89.1015	NM_014763
MRPL19	hsa-miR-520e-5p	88.8665	NM_014763
MRPL19	hsa-miR-4797-5p	88.7101	NM_014763
MRPL19	hsa-miR-10522-5p	87.8037	NM_014763
MRPL19	hsa-miR-218-5p	87.4811	NM_014763
MRPL19	hsa-miR-30e-5p	87.1259	NM_014763
MRPL19	hsa-miR-3613-3p	86.4894	NM_014763
MRPL19	hsa-miR-30d-5p	85.8751	NM_014763
MRPL19	hsa-miR-30a-5p	85.8751	NM_014763
MRPL19	hsa-miR-30b-5p	85.8751	NM_014763
MRPL19	hsa-miR-30c-5p	85.8751	NM_014763
MRPL19	hsa-miR-548t-5p	85.8043	NM_014763
MRPL19	hsa-miR-548az-5p	85.8043	NM_014763
MRPL19	hsa-miR-577	85.5064	NM_014763
MRPL19	hsa-miR-190a-3p	85.1071	NM_014763
MRPL19	hsa-miR-6843-3p	84.7846	NM_014763
MRPL19	hsa-miR-6848-3p	84.7846	NM_014763
MRPL19	hsa-miR-3065-5p	84.7503	NM_014763
MRPL19	hsa-miR-6731-5p	84.2735	NM_014763
MRPL19	hsa-miR-8085	84.2735	NM_014763
MRPL19	hsa-miR-6817-3p	83.8206	NM_014763
MRPL19	hsa-miR-4677-5p	83.5137	NM_014763
MRPL19	hsa-miR-766-5p	83.4899	NM_014763
MRPL19	hsa-miR-4307	83.0006	NM_014763
MRPL19	hsa-miR-4441	81.4082	NM_014763
MRPL19	hsa-miR-34b-3p	81.3941	NM_014763

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Motifs and transcription factors (TFs) regulating MRPL19

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MRPL19	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
MRPL19	transfac_pro__M00652	NRF1 (directAnnotation).
MRPL19	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."