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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MRFAP1

Summary for MRFAP1

Gene information	Gene symbol	MRFAP1
	Ensembl ID	ENSG00000179010
	Entrez ID	93621
	Gene name	Morf4 family associated protein 1
	Synonyms	PAM14\|PGR1
	Gene type	protein_coding
	UniProtAcc	Q9Y605

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Dataset with differentially expressed gene: MRFAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.604344	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.268216	4.53e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.820728	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.288737	4.61e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.758803	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.394441	8.83e-44
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.425585	0.00e+00

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Expression of MRFAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MRFAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MRFAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MRFAP1	hsa-miR-498-5p	95.5634	NM_033296
MRFAP1	hsa-miR-371b-5p	93.2669	NM_001272053
MRFAP1	hsa-miR-373-5p	93.2669	NM_001272053
MRFAP1	hsa-miR-616-5p	93.2669	NM_001272053
MRFAP1	hsa-miR-4524b-3p	91.8166	NM_033296
MRFAP1	hsa-miR-6843-3p	91.2779	NM_001272053
MRFAP1	hsa-miR-6848-3p	91.2779	NM_001272053
MRFAP1	hsa-miR-4477a	90.8237	NM_001272053
MRFAP1	hsa-miR-342-3p	90.7551	NM_033296
MRFAP1	hsa-let-7a-2-3p	90.7155	NM_033296
MRFAP1	hsa-let-7g-3p	90.7155	NM_033296
MRFAP1	hsa-miR-142-3p	88.5539	NM_001272053
MRFAP1	hsa-miR-6821-3p	88.383	NM_001272053
MRFAP1	hsa-miR-5003-3p	88.0848	NM_001272053
MRFAP1	hsa-miR-6790-3p	86.5405	NM_001272053
MRFAP1	hsa-miR-6764-3p	85.5191	NM_001272053
MRFAP1	hsa-miR-6824-3p	85.5191	NM_001272053
MRFAP1	hsa-miR-3143	85.2302	NM_001272053
MRFAP1	hsa-miR-8068	84.7495	NM_033296
MRFAP1	hsa-miR-424-3p	82.5708	NM_001272053
MRFAP1	hsa-miR-3148	81.0447	NM_033296
MRFAP1	hsa-miR-302c-5p	80.2812	NM_001272053
MRFAP1	hsa-miR-11399	80.0851	NM_033296

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Motifs and transcription factors (TFs) regulating MRFAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MRFAP1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
MRFAP1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
MRFAP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MRFAP1	transfac_pro__M04950	EGR1 (directAnnotation).
MRFAP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MRFAP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MRFAP1	transfac_pro__M00652	NRF1 (directAnnotation).
MRFAP1	transfac_pro__M04866	HDAC2 (directAnnotation).
MRFAP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MRFAP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MRFAP1	metacluster_151.2	ZNF23 (directAnnotation).
MRFAP1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
MRFAP1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
MRFAP1	transfac_public__M00040	ATF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."