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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MPZL2

Summary for MPZL2

Gene information	Gene symbol	MPZL2
	Ensembl ID	ENSG00000149573
	Entrez ID	10205
	Gene name	myelin protein zero like 2
	Synonyms	EVA\|EVA1
	Gene type	protein_coding
	UniProtAcc	O60487

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Dataset with differentially expressed gene: MPZL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.17117	1.18e-18

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Expression of MPZL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MPZL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MPZL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MPZL2	hsa-miR-411-3p	99.1395	NM_005797
MPZL2	hsa-miR-379-3p	99.1395	NM_005797
MPZL2	hsa-miR-145-5p	98.4393	NM_005797
MPZL2	hsa-miR-5195-3p	98.4393	NM_005797
MPZL2	hsa-miR-548f-3p	97.1857	NM_005797
MPZL2	hsa-miR-548a-3p	97.1857	NM_005797
MPZL2	hsa-miR-548ar-3p	97.0359	NM_005797
MPZL2	hsa-miR-548bc	96.3381	NM_005797
MPZL2	hsa-miR-548e-3p	96.3381	NM_005797
MPZL2	hsa-miR-548az-3p	96.3381	NM_005797
MPZL2	hsa-miR-4524a-3p	95.4892	NM_005797
MPZL2	hsa-miR-625-5p	94.8166	NM_005797
MPZL2	hsa-miR-545-5p	94.1285	NM_005797
MPZL2	hsa-miR-8068	93.5391	NM_005797
MPZL2	hsa-miR-4495	92.4813	NM_005797
MPZL2	hsa-miR-380-3p	91.9252	NM_005797
MPZL2	hsa-miR-4714-3p	91.4348	NM_144765
MPZL2	hsa-miR-3614-3p	91.0496	NM_005797
MPZL2	hsa-miR-4498	90.1177	NM_144765
MPZL2	hsa-miR-4492	89.0595	NM_144765
MPZL2	hsa-miR-1275	89.0085	NM_005797
MPZL2	hsa-miR-3148	88.5256	NM_005797
MPZL2	hsa-miR-3611	87.9129	NM_005797
MPZL2	hsa-miR-5196-5p	87.264	NM_005797
MPZL2	hsa-miR-4747-5p	87.264	NM_005797
MPZL2	hsa-miR-762	85.9189	NM_144765
MPZL2	hsa-miR-5001-5p	85.9189	NM_144765
MPZL2	hsa-miR-4668-5p	85.75	NM_005797
MPZL2	hsa-miR-6765-3p	84.7735	NM_005797
MPZL2	hsa-miR-4422	84.6671	NM_005797
MPZL2	hsa-miR-4665-5p	84.5798	NM_005797
MPZL2	hsa-miR-7977	84.3516	NM_005797
MPZL2	hsa-miR-548c-3p	83.3068	NM_005797
MPZL2	hsa-miR-1284	82.1322	NM_005797
MPZL2	hsa-miR-582-5p	81.5755	NM_005797
MPZL2	hsa-miR-6876-5p	80.6687	NM_005797
MPZL2	hsa-miR-4476	80.6687	NM_005797
MPZL2	hsa-miR-200a-3p	80.4282	NM_005797
MPZL2	hsa-miR-141-3p	80.4282	NM_005797
MPZL2	hsa-miR-499a-5p	80.4186	NM_144765
MPZL2	hsa-miR-5007-3p	80.3086	NM_005797

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Motifs and transcription factors (TFs) regulating MPZL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."