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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MPZ

Summary for MPZ

Gene information	Gene symbol	MPZ
	Ensembl ID	ENSG00000158887
	Entrez ID	4359
	Gene name	myelin protein zero
	Synonyms	CMT1\|CMT1B\|CMT2I\|CMT2J\|HMSNIB\|P0
	Gene type	protein_coding
	UniProtAcc	P25189

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Dataset with differentially expressed gene: MPZ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	1.50035	0.00e+00

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Expression of MPZ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MPZ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MPZ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MPZ	hsa-miR-8080	98.0221	NM_000530
MPZ	hsa-miR-4477b	96.1326	NM_000530
MPZ	hsa-miR-4697-3p	95.2257	NM_001315491
MPZ	hsa-miR-7111-5p	94.5384	NM_000530
MPZ	hsa-miR-4723-5p	93.5196	NM_000530
MPZ	hsa-miR-7110-3p	93.1507	NM_001315491
MPZ	hsa-miR-6816-3p	92.782	NM_000530
MPZ	hsa-miR-6870-5p	92.4341	NM_000530
MPZ	hsa-miR-5698	92.4341	NM_000530
MPZ	hsa-miR-1304-5p	90.9616	NM_000530
MPZ	hsa-miR-1185-1-3p	89.6303	NM_001315491
MPZ	hsa-miR-1185-2-3p	89.6303	NM_001315491
MPZ	hsa-let-7f-2-3p	89.6303	NM_001315491
MPZ	hsa-miR-6132	89.2853	NM_000530
MPZ	hsa-miR-6836-5p	89.2853	NM_000530
MPZ	hsa-miR-1299	87.5673	NM_001315491
MPZ	hsa-miR-637	87.1249	NM_000530
MPZ	hsa-miR-1275	86.1637	NM_000530
MPZ	hsa-miR-625-5p	85.4242	NM_000530
MPZ	hsa-miR-4757-3p	85.1195	NM_000530
MPZ	hsa-miR-5093	84.7747	NM_001315491
MPZ	hsa-miR-1207-5p	84.4077	NM_000530
MPZ	hsa-miR-5010-5p	84.2947	NM_000530
MPZ	hsa-miR-4525	84.2947	NM_000530
MPZ	hsa-miR-4731-5p	84.2211	NM_000530
MPZ	hsa-miR-875-3p	83.3464	NM_001315491
MPZ	hsa-miR-1226-5p	82.8213	NM_000530
MPZ	hsa-miR-1253	82.4952	NM_001315491
MPZ	hsa-miR-223-3p	82.2543	NM_001315491
MPZ	hsa-miR-6500-3p	81.441	NM_000530
MPZ	hsa-miR-548d-3p	80.9616	NM_001315491
MPZ	hsa-miR-548z	80.2537	NM_001315491
MPZ	hsa-miR-548bb-3p	80.2537	NM_001315491
MPZ	hsa-miR-548h-3p	80.2537	NM_001315491
MPZ	hsa-miR-548ac	80.2537	NM_001315491
MPZ	hsa-miR-219b-3p	80.1945	NM_001315491

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Motifs and transcription factors (TFs) regulating MPZ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MPZ	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."