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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MPRIP

Summary for MPRIP

Gene information	Gene symbol	MPRIP
	Ensembl ID	ENSG00000133030
	Entrez ID	23164
	Gene name	myosin phosphatase Rho interacting protein
	Synonyms	M-RIP\|p116Rip\|RHOIP3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MPRIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.344776	5.18e-12
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.471288	2.13e-33
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.456332	3.64e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.816037	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.356018	4.98e-12

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Expression of MPRIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MPRIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MPRIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MPRIP	hsa-miR-6876-5p	99.9059	NM_201274
MPRIP	hsa-miR-4476	99.9059	NM_201274
MPRIP	hsa-miR-4533	99.3124	NM_201274
MPRIP	hsa-miR-429	96.6077	NM_201274
MPRIP	hsa-miR-200c-3p	96.6077	NM_201274
MPRIP	hsa-miR-200b-3p	96.6077	NM_201274
MPRIP	hsa-miR-548aw	94.7741	NM_201274
MPRIP	hsa-miR-4526	93.7916	NM_201274
MPRIP	hsa-miR-3660	93.7916	NM_201274
MPRIP	hsa-miR-7113-5p	93.3996	NM_201274
MPRIP	hsa-miR-8084	92.3267	NM_201274
MPRIP	hsa-miR-542-3p	90.6757	NM_015134
MPRIP	hsa-miR-4697-3p	90.4932	NM_015134
MPRIP	hsa-miR-21-5p	89.6096	NM_201274
MPRIP	hsa-miR-2113	88.3901	NM_015134
MPRIP	hsa-miR-4308	88.2871	NM_201274
MPRIP	hsa-miR-4492	88.2802	NM_015134
MPRIP	hsa-miR-6849-3p	88.1541	NM_201274
MPRIP	hsa-miR-4668-3p	88.1216	NM_015134
MPRIP	hsa-miR-1252-5p	87.9869	NM_201274
MPRIP	hsa-miR-590-5p	87.6622	NM_201274
MPRIP	hsa-miR-888-3p	87.4001	NM_201274
MPRIP	hsa-miR-548aj-5p	87.0182	NM_201274
MPRIP	hsa-miR-548x-5p	87.0182	NM_201274
MPRIP	hsa-miR-548g-5p	87.0182	NM_201274
MPRIP	hsa-miR-548f-5p	87.0182	NM_201274
MPRIP	hsa-miR-5690	86.7761	NM_201274
MPRIP	hsa-miR-548aa	86.6708	NM_201274
MPRIP	hsa-miR-548ap-3p	86.6708	NM_201274
MPRIP	hsa-miR-548t-3p	86.6708	NM_201274
MPRIP	hsa-miR-22-5p	86.5125	NM_015134
MPRIP	hsa-miR-524-5p	86.0121	NM_201274
MPRIP	hsa-miR-4731-5p	85.6418	NM_015134
MPRIP	hsa-miR-3689f	85.3326	NM_201274
MPRIP	hsa-miR-3689e	85.3326	NM_201274
MPRIP	hsa-miR-3689a-5p	85.3326	NM_201274
MPRIP	hsa-miR-3689b-5p	85.3326	NM_201274
MPRIP	hsa-miR-1227-5p	85.2679	NM_015134
MPRIP	hsa-miR-6073	84.2721	NM_015134
MPRIP	hsa-miR-520d-5p	83.8307	NM_201274
MPRIP	hsa-miR-1468-3p	83.7999	NM_201274
MPRIP	hsa-miR-548m	83.7593	NM_015134
MPRIP	hsa-miR-7977	83.0411	NM_201274
MPRIP	hsa-miR-548ba	82.979	NM_015134
MPRIP	hsa-miR-548ai	82.979	NM_015134
MPRIP	hsa-miR-570-5p	82.979	NM_015134
MPRIP	hsa-miR-548ag	82.979	NM_015134
MPRIP	hsa-miR-4501	82.7218	NM_015134
MPRIP	hsa-miR-570-3p	82.6535	NM_015134
MPRIP	hsa-miR-4755-3p	82.4016	NM_015134

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Motifs and transcription factors (TFs) regulating MPRIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MPRIP	transfac_pro__M05770	ZNF77 (directAnnotation).
MPRIP	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
MPRIP	transfac_pro__M01253	CNOT3 (directAnnotation).
MPRIP	transfac_pro__M04817	ZBTB33 (directAnnotation).
MPRIP	swissregulon__hs__ELF2	ELF2 (directAnnotation).
MPRIP	metacluster_127.2	FOXA1; FOXA2; FOXA3; FOXC1; FOXC1; FOXC2; FOXD1; FOXD1; FOXF2; FOXF2; FOXJ1; FOXK2; FOXK2; FOXO6; FOXP1; FOXP1; FOXP1; FOXP1 (directAnnotation). FOXD2; FOXF1; FOXL3; FOXO1; FOXO3 (inferredBy_Orthology).
MPRIP	metacluster_134.3	FOXA1; FOXA1; FOXC1; FOXG1; FOXG1; FOXI1; FOXJ3; FOXJ3; FOXJ3; FOXK2; FOXL2; FOXO1; FOXO1; FOXO1; FOXO3; FOXO3; FOXO4; FOXO4; FOXO4; FOXP1; FOXP1; FOXP2; FOXP2; FOXP2 (directAnnotation). FOXD1; FOXJ2; FOXJ2; FOXJ3; FOXK1; FOXL2; FOXL2; FOXL2; FOXO1; FOXO3; FOXO3; FOXP2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."