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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MPEG1

Summary for MPEG1

Gene information	Gene symbol	MPEG1
	Ensembl ID	ENSG00000197629
	Entrez ID	219972
	Gene name	macrophage expressed 1
	Synonyms	MPG1
	Gene type	protein_coding
	UniProtAcc	Q2M385

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Dataset with differentially expressed gene: MPEG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.681877	6.09e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.419302	3.69e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.815533	2.95e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.455955	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-1.00783	1.64e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.557255	6.65e-12

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Expression of MPEG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MPEG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MPEG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MPEG1	hsa-miR-6867-5p	99.9999	NM_001039396
MPEG1	hsa-miR-155-5p	95.8623	NM_001039396
MPEG1	hsa-miR-5700	93.2622	NM_001039396
MPEG1	hsa-miR-3166	91.4022	NM_001039396
MPEG1	hsa-miR-586	91.3283	NM_001039396
MPEG1	hsa-miR-372-5p	91.0356	NM_001039396
MPEG1	hsa-miR-875-3p	89.5975	NM_001039396
MPEG1	hsa-miR-12127	88.3665	NM_001039396
MPEG1	hsa-miR-300	87.0684	NM_001039396
MPEG1	hsa-miR-381-3p	87.0684	NM_001039396
MPEG1	hsa-miR-548c-3p	86.4108	NM_001039396
MPEG1	hsa-miR-3148	84.8166	NM_001039396
MPEG1	hsa-miR-4257	83.8524	NM_001039396
MPEG1	hsa-miR-1273h-3p	83.2152	NM_001039396
MPEG1	hsa-miR-4276	82.313	NM_001039396
MPEG1	hsa-miR-33a-3p	81.2289	NM_001039396
MPEG1	hsa-miR-6879-3p	81.0009	NM_001039396

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Motifs and transcription factors (TFs) regulating MPEG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MPEG1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
MPEG1	transfac_pro__M04722	SPI1 (directAnnotation).
MPEG1	hdpi__FLI1	FLI1 (directAnnotation).
MPEG1	swissregulon__hs__SPI1	SPI1 (directAnnotation).
MPEG1	transfac_pro__M06479	ZNF101 (directAnnotation).
MPEG1	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
MPEG1	metacluster_68.7	MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY (directAnnotation). MEIS1; MEIS1; MEIS1; MEIS1; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; MEIS3; PBX1; PBX1; PBX1; PBX2; PBX2; PBX2; PBX3; PBX3; PBX3; PBX4; PBX4; PBX4; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY; TGIF2LY (inferredBy_Orthology).
MPEG1	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
MPEG1	transfac_pro__M05852	ZNF689 (directAnnotation).
MPEG1	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
MPEG1	hdpi__SSX3	SSX3 (directAnnotation).
MPEG1	transfac_pro__M06752	ZNF337 (directAnnotation).
MPEG1	transfac_pro__M01229	GTF2IRD1 (directAnnotation).
MPEG1	tfdimers__MD00387	FOXM1; OTX1; OTX2 (directAnnotation).
MPEG1	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
MPEG1	tfdimers__MD00115	E2F1; NR1I2; RXRA (directAnnotation).
MPEG1	transfac_pro__M05613	ZNF35 (directAnnotation).
MPEG1	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
MPEG1	tfdimers__MD00174	PDX1; STAT6 (directAnnotation).
MPEG1	transfac_pro__M06795	ZNF780B (directAnnotation).
MPEG1	transfac_pro__M06712	ZNF287 (directAnnotation).
MPEG1	transfac_pro__M06252	ZNF415 (directAnnotation).
MPEG1	transfac_pro__M06153	ZNF83 (directAnnotation).
MPEG1	transfac_pro__M06659	ZSCAN10 (directAnnotation).
MPEG1	tfdimers__MD00274	MYCN (directAnnotation).
MPEG1	tfdimers__MD00018	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SPI1; SPIB; TAF6; TBP (directAnnotation).
MPEG1	transfac_pro__M06015	ZNF729 (directAnnotation).
MPEG1	transfac_pro__M04923	ZBTB33 (directAnnotation).
MPEG1	tfdimers__MD00064	E2F1; LTF (directAnnotation).
MPEG1	hocomoco__HMBX1_HUMAN.H11MO.0.D	HMBOX1 (directAnnotation).
MPEG1	transfac_pro__M06116	ZNF28 (directAnnotation).
MPEG1	metacluster_70.17	POU1F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."