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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MPDZ

Summary for MPDZ

Gene information	Gene symbol	MPDZ
	Ensembl ID	ENSG00000107186
	Entrez ID	8777
	Gene name	multiple PDZ domain crumbs cell polarity complex component
	Synonyms	MUPP1
	Gene type	protein_coding
	UniProtAcc	O75970

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Dataset with differentially expressed gene: MPDZ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.48423	0.00e+00

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Expression of MPDZ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MPDZ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MPDZ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MPDZ	hsa-miR-4524a-5p	95.0937	NM_001261406
MPDZ	hsa-miR-4524b-5p	95.0937	NM_001261406
MPDZ	hsa-miR-3163	95.0732	NM_001261406
MPDZ	hsa-miR-2053	94.3856	NM_001261406
MPDZ	hsa-miR-4753-3p	93.6349	NM_001261406
MPDZ	hsa-miR-200c-3p	92.7935	NM_001261406
MPDZ	hsa-miR-429	92.7935	NM_001261406
MPDZ	hsa-miR-200b-3p	92.7935	NM_001261406
MPDZ	hsa-miR-4517	92.4895	NM_001261406
MPDZ	hsa-miR-3941	92.0172	NM_001261406
MPDZ	hsa-miR-4672	92.0172	NM_001261406
MPDZ	hsa-miR-4699-3p	91.4985	NM_001261406
MPDZ	hsa-miR-3609	89.7957	NM_001261406
MPDZ	hsa-miR-548ah-5p	89.7957	NM_001261406
MPDZ	hsa-miR-6165	89.5597	NM_001261406
MPDZ	hsa-miR-3148	89.3875	NM_001261406
MPDZ	hsa-miR-466	89.3038	NM_001261406
MPDZ	hsa-miR-4670-3p	88.9588	NM_001261406
MPDZ	hsa-miR-520d-5p	88.6079	NM_001261406
MPDZ	hsa-miR-524-5p	88.6079	NM_001261406
MPDZ	hsa-miR-203a-3p	87.529	NM_001261406
MPDZ	hsa-miR-3974	87.2834	NM_001261406
MPDZ	hsa-miR-4801	86.628	NM_001261406
MPDZ	hsa-miR-153-5p	86.5074	NM_001261406
MPDZ	hsa-miR-320a-5p	85.8614	NM_001261406
MPDZ	hsa-miR-374b-3p	85.6137	NM_001261406
MPDZ	hsa-miR-1537-5p	84.3119	NM_001261406
MPDZ	hsa-miR-4326	83.8631	NM_001261406
MPDZ	hsa-miR-4731-3p	83.1742	NM_001261406
MPDZ	hsa-miR-569	82.8086	NM_001261406
MPDZ	hsa-miR-3164	82.7201	NM_001261406
MPDZ	hsa-miR-6820-3p	82.7201	NM_001261406
MPDZ	hsa-miR-12123	82.6001	NM_001261406
MPDZ	hsa-miR-3160-5p	82.5688	NM_001261406
MPDZ	hsa-miR-20a-3p	80.5305	NM_001261406

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Motifs and transcription factors (TFs) regulating MPDZ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MPDZ	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MPDZ	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
MPDZ	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MPDZ	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."