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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOSMO

Summary for MOSMO

Gene information	Gene symbol	MOSMO
	Ensembl ID	ENSG00000284487
	Entrez ID	730094
	Gene name	modulator of smoothened
	Synonyms	ATTHOG\|BC030336\|C16orf52
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MOSMO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.353302	0.00e+00

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Expression of MOSMO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOSMO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOSMO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOSMO	hsa-miR-190a-3p	99.9837	NM_001164579
MOSMO	hsa-miR-5011-5p	99.9264	NM_001164579
MOSMO	hsa-miR-8485	99.8941	NM_001164579
MOSMO	hsa-miR-205-5p	99.8147	NM_001164579
MOSMO	hsa-miR-3934-3p	99.7633	NM_001164579
MOSMO	hsa-miR-3163	99.6477	NM_001164579
MOSMO	hsa-miR-2052	99.4237	NM_001164579
MOSMO	hsa-miR-1185-2-3p	98.8695	NM_001164579
MOSMO	hsa-miR-1185-1-3p	98.8695	NM_001164579
MOSMO	hsa-let-7f-2-3p	98.8695	NM_001164579
MOSMO	hsa-miR-128-3p	97.8534	NM_001164579
MOSMO	hsa-miR-216a-3p	97.8534	NM_001164579
MOSMO	hsa-miR-3941	97.1057	NM_001164579
MOSMO	hsa-miR-4733-3p	96.9108	NM_001164579
MOSMO	hsa-miR-3681-3p	96.9	NM_001164579
MOSMO	hsa-miR-4255	96.4265	NM_001164579
MOSMO	hsa-miR-19a-5p	95.9223	NM_001164579
MOSMO	hsa-miR-19b-2-5p	95.9223	NM_001164579
MOSMO	hsa-miR-19b-1-5p	95.9223	NM_001164579
MOSMO	hsa-miR-1468-3p	95.8875	NM_001164579
MOSMO	hsa-miR-548z	94.7836	NM_001164579
MOSMO	hsa-miR-548h-3p	94.7836	NM_001164579
MOSMO	hsa-miR-548d-3p	94.7836	NM_001164579
MOSMO	hsa-miR-548bb-3p	94.7836	NM_001164579
MOSMO	hsa-miR-548ac	94.7836	NM_001164579
MOSMO	hsa-miR-122b-5p	94.349	NM_001164579
MOSMO	hsa-miR-4768-3p	93.7572	NM_001164579
MOSMO	hsa-miR-545-3p	93.6785	NM_001164579
MOSMO	hsa-miR-4742-3p	93.6573	NM_001164579
MOSMO	hsa-miR-519c-3p	93.1514	NM_001164579
MOSMO	hsa-miR-519b-3p	93.1514	NM_001164579
MOSMO	hsa-miR-519a-3p	93.1514	NM_001164579
MOSMO	hsa-miR-330-3p	93.0184	NM_001164579
MOSMO	hsa-miR-3059-5p	92.7128	NM_001164579
MOSMO	hsa-miR-4291	92.5164	NM_001164579
MOSMO	hsa-miR-5002-5p	92.2553	NM_001164579
MOSMO	hsa-miR-429	92.1066	NM_001164579
MOSMO	hsa-miR-4775	91.7861	NM_001164579
MOSMO	hsa-miR-200b-3p	91.4336	NM_001164579
MOSMO	hsa-miR-200c-3p	91.4336	NM_001164579
MOSMO	hsa-miR-5683	91.4182	NM_001164579
MOSMO	hsa-miR-548aj-3p	91.3682	NM_001164579
MOSMO	hsa-miR-548x-3p	91.3682	NM_001164579
MOSMO	hsa-miR-5579-3p	91.2772	NM_001164579
MOSMO	hsa-miR-767-5p	91.1354	NM_001164579
MOSMO	hsa-miR-4711-5p	90.7891	NM_001164579
MOSMO	hsa-miR-582-5p	90.7856	NM_001164579
MOSMO	hsa-miR-6077	90.7719	NM_001164579
MOSMO	hsa-miR-603	90.3628	NM_001164579
MOSMO	hsa-miR-6740-5p	89.7041	NM_001164579

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Motifs and transcription factors (TFs) regulating MOSMO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."